Browsing by Subject "Pulmonary complications"

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    Non-infectious pulmonary complications of hematopoietic stem cell transplantation
    (Thieme, 2014-09) Rowan, Courtney; Baloglu, Orkun; McArthur, Jennifer; Pediatrics, School of Medicine
    Noninfectious pulmonary complications of hematopoietic stem cell transplant are currently more prevalent than infectious complications. Unfortunately, the pathophysiology basis is not completely understood. However, there is a string association with graft-versus-host disease for many of them. Therefore, an important component of their pathophysiology is likely an allo-immune response. There is much research that needs to be conducted to improve the less than optimal outcomes for these disorders.
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    Pulmonary Complications of Pediatric Hematopoietic Cell Transplantation. A National Institutes of Health Workshop Summary
    (American Thoracic Society, 2021) Tamburro, Robert F.; Cooke, Kenneth R.; Davies, Stella M.; Goldfarb, Samuel; Hagood, James S.; Srinivasan, Ashok; Steiner, Marie E.; Stokes, Dennis; DiFronzo, Nancy; El-Kassar, Nahed; Shelburne, Nonniekaye; Natarajan, Aruna; Pulmonary Complications of Pediatric Hematopoietic Cell Transplantation Workshop Participants; Medicine, School of Medicine
    Approximately 2,500 pediatric hematopoietic cell transplants (HCTs), most of which are allogeneic, are performed annually in the United States for life-threatening malignant and nonmalignant conditions. Although HCT is undertaken with curative intent, post-HCT complications limit successful outcomes, with pulmonary dysfunction representing the leading cause of nonrelapse mortality. To better understand, predict, prevent, and/or treat pulmonary complications after HCT, a multidisciplinary group of 33 experts met in a 2-day National Institutes of Health Workshop to identify knowledge gaps and research strategies most likely to improve outcomes. This summary of Workshop deliberations outlines the consensus focus areas for future research.