Browsing by Subject "Polyfluoroarylation"

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    Photoredox Polyfluoroarylation of Alkyl Halides via Halogen Atom Transfer
    (American Chemical Society, 2022) Niu, Ben; Sachidanandan, Krishnakumar; Blackburn, Bryan G.; Cooke, Maria Victoria; Laulhé, Sébastien; Chemistry and Chemical Biology, School of Science
    Polyfluoroarene moieties are of interest in medicinal chemistry, agrochemicals, and material sciences. Herein, we present the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method converts primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds in good yields in the presence of amide, carbamate, ester, aromatic, and sulfonamide moieties, including derivatives of complex bioactive molecules. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after the halogen atom transfer.