Browsing by Subject "Osteoporosis, Postmenopausal"

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    The microenvironment matters: estrogen deficiency fuels cancer bone metastases
    (American Association for Cancer Research, 2014-06-01) Wright, Laura E.; Guise, Theresa A.; Department of Medicine, IU School of Medicine
    Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.