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Item A survey of informatics platforms that enable distributed comparative effectiveness research using multi-institutional heterogeneous clinical data(Wolters Kluwer, 2012) Sittig, Dean F.; Hazlehurst, Brian L.; Brown, Jeffrey; Murphy, Shawn; Rosenman, Marc; Tarczy-Hornoch, Peter; Wilcox, Adam B.; Pediatrics, School of MedicineComparative effectiveness research (CER) has the potential to transform the current health care delivery system by identifying the most effective medical and surgical treatments, diagnostic tests, disease prevention methods, and ways to deliver care for specific clinical conditions. To be successful, such research requires the identification, capture, aggregation, integration, and analysis of disparate data sources held by different institutions with diverse representations of the relevant clinical events. In an effort to address these diverse demands, there have been multiple new designs and implementations of informatics platforms that provide access to electronic clinical data and the governance infrastructure required for interinstitutional CER. The goal of this manuscript is to help investigators understand why these informatics platforms are required and to compare and contrast 6 large-scale, recently funded, CER-focused informatics platform development efforts. We utilized an 8-dimension, sociotechnical model of health information technology to help guide our work. We identified 6 generic steps that are necessary in any distributed, multi-institutional CER project: data identification, extraction, modeling, aggregation, analysis, and dissemination. We expect that over the next several years these projects will provide answers to many important, and heretofore unanswerable, clinical research questions.Item Event Notification in Support of Population Health: The Promise and Challenges from a Randomized Controlled Trial(IOS Press, 2017) Dixon, Brian E.; Boockvar, Kenneth S.; Epidemiology, School of Public HealthEvent notifications are real-time, electronic alerts that have the promise of improving population health by exchanging critical information to a patient's extended care team. In a trial of event noficiations in U.S. Veterans Affairs facilities, we seek to understand the impact of notifications on health care utilization within 30 and 90-days. Lessons from the trial have implications beyond the evidence by informing strategies to develop and implement event notifications in other health systems.