Browsing by Subject "Network topology"

Now showing 1 - 3 of 3
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    CentFlow: Centrality-Based Flow Balancing and Traffic Distribution for Higher Network Utilization
    (IEEE, 2017) Challa, R.; Jeon, S.; Kim, D. S.; Choo, H.; Electrical and Computer Engineering, School of Engineering and Technology
    Next-generation networks (NGNs) are embracing two key principles of software defined networking (SDN) paradigm functional segregation of control and forwarding plane, and logical centralization of the control plane. A centralized control enhances the network management significantly by regulating the traffic distribution dynamically and effectively. An eagle-eye view of the entire topology opens up the opportunity for an SDN controller to refine the routing. Optimizing the network utilization in terms of throughput is majorly dependent on the routing decisions. Open Shortest Path First (OSPF) and Intermediate System to Intermediate System (IS-IS) are well-known traditional link state routing protocols proven with operation over operator networks for a long time. However, these classical protocols deployed distributively fall short of expectation in addressing the current routing issues due to the lack of a holistic view of the network topology and situation, whereas handling enormous traffic and user quality of experience (QoE) requirements are getting critical. IP routing in NGN is widely expected to be supported by SDN to enhance the network utilization in terms of throughput. We propose a novel routing algorithm-CentFlow, for an SDN domain to boost up the network utilization. The proposed weight functions in CentFlow achieve smart traffic distribution by detecting highly utilized nodes depending on the centrality measures and the temporal node degree that changes based on node utilization. Furthermore, the frequently selected edges are penalized thereby augmenting the flow balancing and dispersion. CentFlow reaps greater benefits on an SDN controller than the classical OSPF due to its comprehensive view of the network. Experimental results show that CentFlow enhances the utilization of up to 62% of nodes and 49% of links, respectively, compared to an existing Dijkstra algorithm-based routing scheme in SDN. Furthermore, nearly 6.5% more flows are processed networ- wide.
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    Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women
    (Nature Research, 2018-11-20) Dugas, Lara R.; Bernabé, Beatriz Peñalver; Priyadarshini, Medha; Fei, Na; Park, Seo Jin; Brown, Laquita; Plange-Rhule, Jacob; Nelson, David; Toh, Evelyn C.; Gao, Xiang; Dong, Qunfeng; Sun, Jun; Kliethermes, Stephanie; Gottel, Neil; Luke, Amy; Gilbert, Jack A.; Layden, Brian T.; Microbiology and Immunology, School of Medicine
    We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed significantly more dietary fiber, had greater microbial alpha-diversity, different beta-diversity, and had a greater concentration of total fecal SCFAs (p-value < 0.002). Lean Ghanaians had significantly greater network density, connectivity and stability than either obese Ghanaians, or lean and obese US participants (false discovery rate (FDR) corrected p-value ≤ 0.01). Bacteroides uniformis was significantly more abundant in lean women, irrespective of country (FDR corrected p < 0.001), while lean Ghanaians had a significantly greater proportion of Ruminococcus callidus, Prevotella copri, and Escherichia coli, and smaller proportions of Lachnospiraceae, Bacteroides and Parabacteroides. Lean Ghanaians had a significantly greater abundance of predicted microbial genes that catalyzed the production of butyric acid via the fermentation of pyruvate or branched amino-acids, while obese Ghanaians and US women (irrespective of BMI) had a significantly greater abundance of predicted microbial genes that encoded for enzymes associated with the fermentation of amino-acids such as alanine, aspartate, lysine and glutamate. Similar to lean Ghanaian women, mice humanized with stool from the lean Ghanaian participant had a significantly lower abundance of family Lachnospiraceae and genus Bacteroides and Parabacteroides, and were resistant to obesity following 6-weeks of high fat feeding (p-value < 0.01). Obesity-resistant mice also showed increased intestinal transcriptional expression of the free fatty acid (Ffa) receptor Ffa2, in spite of similar fecal SCFAs concentrations. We demonstrate that the association between obesity resistance and increased predicted ecological connectivity and stability of the lean Ghanaian microbiota, as well as increased local SCFA receptor level, provides evidence of the importance of robust gut ecologic network in obesity.
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    Sex-specific topological structure associated with dementia via latent space estimation
    (Wiley, 2024) Wang, Selena; Wang, Yiting; Xu, Frederick H.; Tian, Xinyuan; Fredericks, Carolyn A.; Shen, Li; Zhao, Yize; Alzheimer’s Disease Neuroimaging Initiative; Biostatistics and Health Data Science, Richard M. Fairbanks School of Public Health
    Introduction: We investigate sex-specific topological structures associated with typical Alzheimer's disease (AD) dementia using a novel state-of-the-art latent space estimation technique. Methods: This study applies a probabilistic approach for latent space estimation that extends current multiplex network modeling approaches and captures the higher-order dependence in functional connectomes by preserving transitivity and modularity structures. Results: We find sex differences in network topology with females showing more default mode network (DMN)-centered hyperactivity and males showing more limbic system (LS)-centered hyperactivity, while both show DMN-centered hypoactivity. We find that centrality plays an important role in dementia-related dysfunction with stronger association between connectivity changes and regional centrality in females than in males. Discussion: The study contributes to the current literature by providing a more comprehensive picture of dementia-related neurodegeneration linking centrality, network segregation, and DMN-centered changes in functional connectomes, and how these components of neurodegeneration differ between the sexes. Highlights: We find evidence supporting the active role network topology plays in neurodegeneration with an imbalance between the excitatory and inhibitory mechanisms that can lead to whole-brain destabilization in dementia patients. We find sex-based differences in network topology with females showing more default mode network (DMN)-centered hyperactivity, males showing more limbic system (LS)-centered hyperactivity, while both show DMN-centered hypoactivity. We find that brain region centrality plays an important role in dementia-related dysfunction with a stronger association between connectivity changes and regional centrality in females than in males. Females, compared to males, tend to exhibit stronger dementia-related changes in regions that are the central actors of the brain networks. Taken together, this research uniquely contributes to the current literature by providing a more comprehensive picture of dementia-related neurodegeneration linking centrality, network segregation, and DMN-centered changes in functional connectomes, and how these components of neurodegeneration differ between the sexes.