Browsing by Subject "Myogenin"

Now showing 1 - 2 of 2
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    Short review of inflammatory rhabdomyoblastic tumor: A newly described entity that does not fit into the current classification of skeletal muscle neoplasms
    (Elsevier, 2022) Boham, Sampson K.; Chen, Shaoxiong; Pathology and Laboratory Medicine, School of Medicine
    Inflammatory rhabdomyoblastic tumor (IRMT), previously called histiocyte-rich rhabdomyoblastic tumor (HRRMT), is a recently described skeletal muscle neoplasm of uncertain malignant potential, commonly affecting young-to-middle aged men, typically arises in the skeletal muscles of the lower extremities and trunk and mostly has an intermediate (rarely metastasizing) clinical behavior. IRMT/HRRMT is commonly characterized by slow growth and encapsulation containing lymphoid aggregates. It is composed of spindle-to-epithelioid cells with a rhabdomyoblastic immunophenotype, a diffuse histiocytic infiltrate, and low mitotic figures. In this review, we will summarize its clinicopathologic features, immunophenotypic and molecular findings, prognosis, and treatment based on currently available published case reports. The purpose of this review is to increase awareness of this rare entity among pathologists and further help clinicians to manage patients properly.
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    Vitamin D and VDR in cancer cachexia and muscle regeneration
    (Impact Journals, 2017-03-28) Camperi, Andrea; Pin, Fabrizio; Costamagna, Domiziana; Penna, Fabio; Lopez Menduina, Maria; Aversa, Zaira; Zimmers, Teresa A.; Verzaro, Roberto; Fittipaldi, Raffaella; Caretti, Giuseppina; Baccino, Francesco Maria; Muscaritoli, Maurizio; Costelli, Paola; Medicine, School of Medicine
    Low circulating levels of vitamin D were associated with decreased muscle strength and physical performance. Along this line, the present study was aimed to investigate: i) the therapeutic potential of vitamin D in cancer-induced muscle wasting; ii) the mechanisms by which vitamin D affects muscle phenotype in tumor-bearing animals.Rats bearing the AH130 hepatoma showed decreased circulating vitamin D compared to control rats, while muscle vitamin D receptor (VDR) mRNA was up-regulated. Both circulating vitamin D and muscle VDR expression increased after vitamin D administration, without exerting appreciable effects on body weight and muscle mass.The effects of vitamin D on muscle cells were studied in C2C12 myocytes. Vitamin D-treated myoblasts did not differentiate properly, fusing only partially and forming multinucleated structures with aberrant shape and low myosin heavy chain content. Vitamin D treatment resulted in VDR overexpression and myogenin down-regulation. Silencing VDR expression in C2C12 cultures abrogated the inhibition of differentiation exerted by vitamin D treatment.These data suggest that VDR overexpression in tumor-bearing animals contributes to muscle wasting by impairing muscle regenerative program. In this regard, attention should be paid when considering vitamin D supplementation to patients affected by chronic pathologies where muscle regeneration may be involved.