Browsing by Subject "Multidetector computed tomography"

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    Cross-sectional imaging-based severity scoring of chronic pancreatitis: why it is necessary and how it can be done
    (SpringerLink, 2020-05) Dasyam, Anil K.; Shah, Zarine K.; Tirkes, Temel; Dasyam, Navya; Borhani, Amir A.; Radiology and Imaging Sciences, School of Medicine
    Chronic pancreatitis (CP) remains a diagnostic challenge as clinical symptoms are non-specific, histopathological appearances are varied and pathogenesis remains incompletely understood. Multiple classifications and grading systems have been proposed for CP, but none leverage the full capabilities of cross-sectional imaging modalities and are not widely accepted or validated. CT and MRI/MRCP are useful in identifying a wide spectrum of histopathological changes in CP and can also assess exocrine reserve of pancreas. Advanced MRI techniques such as T1 mapping and extracellular volume fraction can potentially identify early CP. Cross-sectional imaging-based severity scoring can quantify CP disease burden and may have positive implications for clinicians and researchers. In this review, we discuss the need for cross-sectional imaging-based severity scoring for CP, role of CT, and MRI/MRCP in assessment of CP and how these modalities can be used to obtain severity scoring for CP. We summarize relevant information from recently published CT and MRI/MRCP reporting standards for CP, and from international guidelines for cross-sectional imaging and severity scoring for CP.
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    Myocardial extracellular volume measurement using cardiac computed tomography
    (Springer, 2024) Muthalaly, Rahul G.; Abrahams, Timothy; Lin, Andrew; Patel, Kush; Tan, Sean; Dey, Damini; Han, Donghee; Tamarappoo, Balaji K.; Nicholls, Stephen J; Nerlekar, Nitesh; Medicine, School of Medicine
    Myocardial fibrosis is a common endpoint of many cardiac diseases and increasingly recognized as a predictor of heart failure, arrhythmia, and death. Recent studies have utilised cardiac computed tomography (CT) scans with delayed phase imaging to quantify diffuse fibrosis of the myocardium. CT extracellular volume (CT-ECV) measurement correlates well with CMR and histological myocardial fibrosis. Furthermore, CT-ECV predicts outcomes such as death, heart failure and arrhythmia in various disease states. This review summarizes the rationale and methodology behind CT-ECV measurement and provides a detailed summary of the current clinical evidence for the use of CT-ECV.