Browsing by Subject "MicroRNA-155"

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    Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer?
    (Wiley, 2015-11) Comer, Brian S.; Department of Cellular and Integrative Physiology, IU School of Medicine
    MicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammation. Inhibition of miR-155 or COX-2 exhibit similar negative effects on tumorigenicity. Thus, it is hypothesized that miR-155 may be a promising target for antagonizing COX-2 expression in colorectal and other cancers.