Browsing by Subject "Metacarpophalangeal pattern profile (MCPP)"

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    Metacarpophalangeal pattern profile analysis in fragile X syndrome
    (Wiley, 1988-12) Butler, M. G; Fletcher, M.; Gale, D. D.; Meaney, F. J.; McLeod, D. R.; Fagan, J.; Carpenter, N. J.; Opitz, J. M.; Reynolds, J. F.; Department of Medical and Molecular Genetics, School of Medicine
    We analyzed the metacarpophalangeal pattern profile (MCPP) on 18 male individuals from 16 families with fragile X—fra (X), or Martin-Bell—syndrome and calculated a mean syndrome profile. Fourteen of 18 individuals with fra (X) syndrome had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with fra (X) syndrome compared with a sample of normal individuals produced a correct classification rate of 88% based on a function of 3 MCPP variables that may provide a useful tool in screening individuals for the fra (X) syndrome. Discriminant and correlation analyses of individuals with Sotos sequence and individuals with fra (X) syndrome did not identify MCPP similarities. Therefore, there was no MCPP evidence in our study of patients with Sotos sequence and fra (X) chromosome expression.
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    Metacarpophalangeal pattern profile analysis in Prader-Willi syndrome. A follow-up report on 38 cases
    (Wiley, 1985-07) Butler, Merlin G.; Meaney, F. John; Medical and Molecular Genetics, School of Medicine
    Metacarpophalangeal pattern profile (MCPP) was determined on 38 Prader-Willi syndrome individuals and compared with a previous report on 16 patients. Chromosome analysis showed an interstitial deletion of the long arm of chromosome 15 in 20 subjects and normal chromosome results in the remaining 18 individuals. The mean hand profile of 38 individuals was essentially flat while the profiles for the two groups based on chromosome findings were separate in the metacarpal area. Correlation studies confirmed the homogeneity of the deletion group relative to Prader-Willi syndrome individuals with normal chromosomes. Discriminant analysis of Prader-Willi syndrome versus control individuals produced a function of three MCPP variables plus age which may be applied as another diagnostic tool.
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    Metacarpophalangeal pattern profile analysis in Robinow syndrome
    (Wiley, 1987-05) Butler, Merlin G.; Gale, David D.; Meaney, F. John; Wadlington, William B.; Robinow, Meinhard; Medical and Molecular Genetics, School of Medicine
    We analyzed the metacarpophalangeal pattern profile (MCPP) on 15 individuals with Robinow syndrome and calculated a mean Robinow syndrome profile. Correlation studies confirm clinical homogeneity of the hand profile in the Robinow syndrome. Discriminant analysis of individuals with Robinow syndrome compared with a sample of normal individuals produces a function of 6 MCPP variable that may provide a useful tool for diagnosis.