Browsing by Subject "Memory performance"

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    Joint Exploration and Mining of Memory-Relevant Brain Anatomic and Connectomic Patterns via a Three-Way Association Model
    (IEE, 2018-04) Yan, Jingwen; Liu, Kefei; Li, Huang; Amico, Enrico; Risacher, Shannon L.; Wu, Yu-Chien; Fang, Shiaofen; Sporns, Olaf; Saykin, Andrew J.; Goñi, Joaquín; Shen, Li; BioHealth Informatics, School of Informatics and Computing
    Early change in memory performance is a key symptom of many brain diseases, but its underlying mechanism remains largely unknown. While structural MRI has been playing an essential role in revealing potentially relevant brain regions, increasing availability of diffusion MRI data (e.g., Human Connectome Project (HCP)) provides excellent opportunities for exploration of their complex coordination. Given the complementary information held in these two imaging modalities, we hypothesize that studying them as a whole, rather than individually, and exploring their association will provide us valuable insights of the memory mechanism. However, many existing association methods, such as sparse canonical correlation analysis (SCCA), only manage to handle two-way association and thus cannot guarantee the selection of biomarkers and associations to be memory relevant. To overcome this limitation, we propose a new outcome-relevant SCCA model (OSCCA) together with a new algorithm to enable the three-way associations among brain connectivity, anatomic structure and episodic memory performance. In comparison with traditional SCCA, we demonstrate the effectiveness of our model with both synthetic and real data from the HCP cohort.
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    Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults
    (medRxiv, 2025-06-02) Eissman, Jaclyn M.; Regelson, Alexandra N.; Walters, Skylar; Archer, Derek B.; Durant, Alaina; Mukherjee, Shubhabrata; Lee, Michael L.; Choi, Seo-Eun; Scollard, Phoebe; Trittschuh, Emily H.; Mez, Jesse; Kang, Moonil; Bush, William S.; Kunkle, Brian W.; Naj, Adam C.; Gifford, Katherine A.; Bilgel, Murat; Kuzma, Amanda B.; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); Alzheimer’s Disease Sequencing Project (ADSP); Cuccaro, Michael L.; Cruchaga, Carlos; Pericak-Vance, Margaret A.; Farrer, Lindsay A.; Wang, Li-San; Schellenberg, Gerard D.; Vardarajan, Badri N.; Mayeux, Richard; Haines, Jonathan L.; Jefferson, Angela L.; Kukull, Walter A.; Keene, C. Dirk; Saykin, Andrew J.; Thompson, Paul M.; Martin, Eden R.; Albert, Marilyn S.; Johnson, Sterling C.; Engelman, Corinne D.; Ferrucci, Luigi; Bennett, David A.; Barnes, Lisa L.; Schneider, Julie A.; Resnick, Susan M.; Sperling, Reisa A.; Crane, Paul K.; Hohman, Timothy J.; Dumitrescu, Logan; Radiology and Imaging Sciences, School of Medicine
    We previously identified sex-specific genetic loci associated with memory performance, a strong Alzheimer's disease (AD) endophenotype. Here, we expand on this work by conducting sex-specific, cross-ancestral, genome-wide meta-analyses of three cognitive domains (memory, executive functioning, and language) in 33,918 older adults (57% female; 41% cognitively impaired; mean age=73 years) from 10 aging and AD cohorts. All three domains were comparably heritable across sexes. Genome-wide meta-analyses identified three novel loci: a female-specific language decline-associated locus, VRK2 (rs13387871), which is a published candidate for neuropsychiatric traits involving language ability; a male-specific memory decline-associated locus among cognitive impaired, DCHS2 (rs12501200), which is a published candidate gene for AD age-at-onset; and a sex-interaction with baseline executive functioning, AGA (rs1380012), among cognitive impaired. We additionally provide evidence for shared genetic architecture between lifetime estrogen exposure and AD-related cognitive decline. Overall, we identified sex-specific variants, genes, and pathways relating to three cognitive domains among older adults.