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Item Metacarpophalangeal pattern profile analysis in diastrophic dysplasia(Wiley, 1987-11) Butler, Merlin G.; Gale, David D.; Meaney, F. John; Medical and Molecular Genetics, School of MedicineWe analyzed the metacarpophalangeal pattern profile (MCPP) on 16 individuals with diastrophic dysplasia and calculated a mean syndrome profile. Correlation studies confirm clinical homogeneity of the hand profile in diastrophic dysplasia. Discriminant analysis of individuals with diastrophic dysplasia compared with a sample of normal individuals produced a function of 3 MCPP variables plus age that appears to be a useful diagnostic tool.