Browsing by Subject "Lung cancer growth and metastasis"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Systemic Platelet-activating Factor Receptor Activation Augments Experimental Lung Tumor Growth and Metastasis
    (Sage, 2014-06-19) Hackler, Patrick C.; Reuss, Sarah; Konger, Raymond L.; Travers, Jeffrey B.; Sahu, Ravi P.; Dermatology, School of Medicine
    Pro-oxidative stressors including cigarette smoke (CS) generate novel lipids with platelet-activated factor-receptor (PAF-R) agonistic activity mediate systemic immunosuppression, one of the most recognized events in promoting carcinogenesis. Our previous studies have established that these oxidized-PAF-R-agonists augment murine B16F10 melanoma tumor growth in a PAF-R-dependent manner because of its effects on host immunity. As CS generates PAF-R agonists, the current studies sought to determine the impact of PAF-R agonists on lung cancer growth and metastasis. Using the murine Lewis Lung Carcinoma (LLC1) model, we demonstrate that treatment of C57BL/6 mice with a PAF-R agonist augments tumor growth and lung metastasis in a PAF-R-dependent manner as these findings were not seen in PAF-R-deficient mice. Importantly, this effect was because of host rather than tumor cells PAF-R dependent as LLC1 cells do not express functional PAF-R. These findings indicate that experimental lung cancer progression can be modulated by the PAF system.