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Browsing by Subject "Lifespan"
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Item Meaning-making processes across the lifespan: An investigation of the developmental course of metacognitive capacity(Elsevier, 2022) Davis, Beshaun J.; Bonfils, Kelsey A.; Zalzala, Aieyat; Lysaker, Paul H.; Minor, Kyle S.; Psychology, School of ScienceDeficits in metacognitive capacity (i.e., the ability to integrate knowledge of oneself and others into a cohesive whole) have been shown to lead to poor functional outcome in psychosis. However, there is a gap in the literature concerning the role of metacognition in typically developing populations, which makes it difficult to define what level of metacognition is normative and at what point deficits in metacognition suggest pathology. To explore this issue, we utilized cross-sectional design to assess metacognitive capacities among 69 neurotypical adults whose ages varied from 18 to 65 using the Metacognitive Assessment Scale - Abbreviated (MAS-A) and then compared those with MAS-A scores from a second previously gathered sample of 360 adults diagnosed with psychosis across four key developmental windows: emerging adulthood, early adulthood, middle adulthood, and late adulthood. Our findings suggest that in our overall sample, individuals with psychosis had significantly lower levels of metacognitive capacity across all domains assessed by the MAS-A in comparison to neurotypical individuals. Additionally, our data suggest a deleterious effect of psychosis such that individuals with psychosis showed significantly lower metacognition in each developmental stage. Additionally, these differences were largest in emerging and late adulthood and for both groups awareness of others stood out as the single metacognitive domain which was significantly less impaired among older groups. Our results suggest a developmental course for metacognitive capacity such that awareness of others is the sole domain that grows over the lifespan.Item The Collaborative Study on the Genetics of Alcoholism: Overview(Wiley, 2023) Agrawal, Arpana; Brislin, Sarah J.; Bucholz, Kathleen K.; Dick, Danielle; Hart, Ronald P.; Johnson, Emma C.; Meyers, Jacquelyn; Salvatore, Jessica; Slesinger, Paul; COGA Collaborators; Almasy, Laura; Foroud, Tatiana; Goate, Alison; Hesselbrock, Victor; Kramer, John; Kuperman, Samuel; Merikangas, Alison K.; Nurnberger, John I.; Tischfield, Jay; Edenberg, Howard J.; Porjesz, Bernice; Medical and Molecular Genetics, School of MedicineAlcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders with etiological origins in the brain and the environment. To outline the causes and consequences of alcohol-related milestones, including AUD, and their related psychiatric comorbidities, the Collaborative Study on the Genetics of Alcoholism (COGA) was launched in 1989 with a gene-brain-behavior framework. COGA is a family based, diverse (~25% self-identified African American, ~52% female) sample, including data on 17,878 individuals, ages 7-97 years, in 2246 families of which a proportion are densely affected for AUD. All participants responded to questionnaires (e.g., personality) and the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) which gathers information on psychiatric diagnoses, conditions and related behaviors (e.g., parental monitoring). In addition, 9871 individuals have brain function data from electroencephalogram (EEG) recordings while 12,009 individuals have been genotyped on genome-wide association study (GWAS) arrays. A series of functional genomics studies examine the specific cellular and molecular mechanisms underlying AUD. This overview provides the framework for the development of COGA as a scientific resource in the past three decades, with individual reviews providing in-depth descriptions of data on and discoveries from behavioral and clinical, brain function, genetic and functional genomics data. The value of COGA also resides in its data sharing policies, its efforts to communicate scientific findings to the broader community via a project website and its potential to nurture early career investigators and to generate independent research that has broadened the impact of gene-brain-behavior research into AUD.Item The collaborative study on the genetics of alcoholism: Sample and clinical data(Wiley, 2023) Dick, Danielle M.; Balcke, Emily; McCutcheon, Vivia; Francis, Meredith; Kuo, Sally; Salvatore, Jessica; Meyers, Jacquelyn; Bierut, Laura J.; Schuckit, Marc; Hesselbrock, Victor; Edenberg, Howard J.; Porjesz, Bernice; COGA Collaborators; Kuperman, Samuel; Kramer, John; Bucholz, Kathleen; Medical and Molecular Genetics, School of MedicineThe collaborative study on the genetics of alcoholism (COGA) is a multi-site, multidisciplinary project with the goal of identifying how genes are involved in alcohol use disorder and related outcomes, and characterizing how genetic risk unfolds across development and in conjunction with the environment and brain function. COGA is a multi-generational family-based study in which probands were recruited through alcohol treatment centers, along with a set of community comparison families. Nearly 18,000 individuals from >2200 families have been assessed over a period of over 30 years with a rich phenotypic battery that includes semi-structured psychiatric interviews and questionnaire measures, along with DNA collection and electrophysiological data on a large subset. Participants range in age from 7 to 97, with many having longitudinal assessments, providing a valuable opportunity to study alcohol use and problems across the lifespan. Here we provide an overview of data collection methods for the COGA sample, and details about sample characteristics and comorbidity. We also review key research findings that have emerged from analyses of the COGA data. COGA data are available broadly to researchers, and we hope this overview will encourage further collaboration and use of these data to advance the field.