Browsing by Subject "Itraconazole pharmacotherapy"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis
    (Hindawi, 2020-02-12) Agrawal, Vaibhav; Brinda, Bryan J.; Farag, Sherif S.; Medicine, School of Medicine
    Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. The patient experienced significant clinical improvement after initiation of itraconazole pharmacotherapy. We recommend a lower threshold for evaluation for histoplasmosis in allogeneic hematopoietic stem cell transplant recipients who live in endemic regions, regardless of their antifungal prophylactic regimen.