Browsing by Subject "Influenza, Human"

Now showing 1 - 3 of 3
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    Altered standards of care for health care providers in the pandemic influenza
    (Indiana University, 2009) Kinney, Eleanor D.; McCabe, Heather A.; Gilbert, Amy Lewis; Shisler, Janna Jo
    Pandemic influenza will pose tremendous challenges to health care providers, state public health authorities, and the public. All will have to conduct business under the most adverse of circumstances. It will be difficult for providers to meet the customary legal standards of care imposed by state and federal regulatory authorities, as well as the common law tort system. This white paper will explore the legal issues associated with altered standards of care in pandemic influenza.
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    The effector T cell response to influenza infection
    (Springer, 2015) Hufford, Matthew M.; Kim, Taeg S.; Sun, Jie; Braciale, Thomas J.; Department of Pediatrics, IU School of Medicine
    Influenza virus infection induces a potent initial innate immune response, which serves to limit the extent of viral replication and virus spread. However, efficient (and eventual) viral clearance within the respiratory tract requires the subsequent activation, rapid proliferation, recruitment, and expression of effector activities by the adaptive immune system, consisting of antibody producing B cells and influenza-specific T lymphocytes with diverse functions. The ensuing effector activities of these T lymphocytes ultimately determine (along with antibodies) the capacity of the host to eliminate the viruses and the extent of tissue damage. In this review, we describe this effector T cell response to influenza virus infection. Based on information largely obtained in experimental settings (i.e., murine models), we will illustrate the factors regulating the induction of adaptive immune T cell responses to influenza, the effector activities displayed by these activated T cells, the mechanisms underlying the expression of these effector mechanisms, and the control of the activation/differentiation of these T cells, in situ, in the infected lungs.
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    The Two Faces of Influenza
    (Association of Kenya Physicians, 2007) Sabine, Arnoux; Association of Kenya Physicians Scientific Conference (11th : Mar. 2007 : Eldoret, Kenya)
    Influenza is often misunderstood and underestimated. Influenza is not just “a bad cold”. Mainly spread through the air by coughing and sneezing, especially in closed public places: public transport, meeting rooms, etc. An infected person can transmit the virus to others from 1-2 days before flu symptoms start, and for 5 days afterwards. Influenza virus mutations: Influenza type A viruses mutate frequently, type B viruses mutate less frequently. Mutation enables the virus to bypass the population’s acquired immunity. Both the haemagglutinin and neuramidase surface antigens mutate.