Browsing by Subject "In Vitro Techniques"
Now showing 1 - 4 of 4
Results Per Page
Sort Options
Item Detection of single cells producing anti-gamma globulin antibodies in vitro(1969) Kapp, Judith AnneItem How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective(Hindawi Publishing Corporation, 2015) Wang, Lei; Chiang, ChienWei; Liang, Hong; Wu, Hengyi; Feng, Weixing; Quinney, Sara K.; Li, Jin; Li, Lang; Department of Obstetrics and Gynecology, IU School of MedicineThe use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe drugs was collated from the literature. Then the performance of different in vitro systems including Escherichia coli system, yeast system, lymphoblastoid system and baculovirus system is compared after in vitro-in vivo extrapolation. Baculovirus system, which can provide most of the data, has almost equal accuracy as the other systems in predicting clearance. And in most cases, baculovirus system has the smaller CV in scaling factors. Therefore, the baculovirus system can be recognized as the suitable system for the large scale drug clearance prediction.Item Metabolism of ibuprofen in vivo and in vitro: formation of "hybrid" lipids(1997) Johnson, Jan LynetteItem Regulation of adipose tissue metabolism(1962) Love, William Clayton