Browsing by Subject "Immunity, Cellular"
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Item Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses(Wiley Blackwell (Blackwell Publishing), 2014-07) Sullivan, J. A.; Jankowska-Gan, E.; Shi, L.; Roenneburg, D.; Hegde, S.; Greenspan, D. S.; Wilkes, D. S.; Denlinger, L. C.; Burlingham, W. J.; Department of Medicine, IU School of MedicineIL17-dependent autoimmunity to collagen type V (Col V) has been associated with lung transplant obliterative bronchiolitis. Unlike the T helper 1 (Th1)-dependent immune responses to Tetanus Toxoid (TT), the Th17 response to Col V in lung transplant patients and its Th1/17 variant observed in coronary artery disease patients requires IL-1β, tumor necrosis factor α and CD14(+) cells. Given the involvement of the P2X7 receptor (P2X7R) in monocyte IL-1β responses, we investigated its role in Th17-, Th1/17- and Th1-mediated proinflammatory responses. Transfer of antigen-pulsed peripheral blood mononucleated cells (PBMCs) from Col V-reactive patients into SCID mouse footpads along with P2X7R antagonists revealed a selective inhibition of Col V-, but not TT-specific swelling responses. P2X7R inhibitors blocked IL-1β induction from monocytes, including both Col V-α1 peptide-induced (T-dependent), as well as native Col V-induced (T-independent) responses. Significantly higher P2X7R expression was found on CXCR3(neg) CCR4(+)/6(+) CD4(+) [Th17] versus CXCR3(+)CCR4/6(neg) CD4(+) [Th1] subsets in PBMCs, suggesting that the paradigm of selective dependence on P2X7R might extend beyond Col V autoimmunity. Indeed, P2X7R inhibitors suppressed not only anti-Col V, but also Th1/17-mediated alloimmunity, in a heart transplant patient without affecting anti-viral Epstein-Barr virus responses. These results suggest that agents targeting the P2X7R might effectively treat Th17-related transplant pathologies, while maintaining Th1-immunity to infection.Item Effect of ultraviolet B light on antibody production to the hapten dinitrophenyl in a murine model(1996) Kingma, Karen SueItem The effects of cyclophosphamide and thymopoietin of the cell-mediated immune response in the guinea pig(1977) Weyhenmeyer, James AlanItem The histological effects of intrauterine and postnatal protein malnutrition on rat thymus, spleen and lymph nodes(1977) Brewer, Erich ThorntonItem IL-9 by INFERence(Elsevier, 2013-10-17) Zhou, Baohua; Kaplan, Mark H.; Department of Pediatrics, IU School of MedicineDespite discovery of the cytokine over 20 years ago, the relevant biological sources of IL-9 have remained a mystery. In this issue of Immunity, Licona-Limón et al. (2013) use a newly generated reporter mouse to demonstrate a role for IL-9-secreting T cells in helminthic parasite immunity.Item Studies of 51-Chromium immune assay for the detection of cell-mediated immunity to herpes simplex virus(1976) Feltt, James Russell