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Item Center for Regenerative Biology and Medicine(Office of the Vice Chancellor for Research, 2010-04-09) Stocum, David L.The Indiana University Center for Regenerative Biology and Medicine (CRBM) was established at IUPUI in 2001 through a grant from the State of Indiana 21st Century Fund. In 2007, the CRBM was selected as an IUPUI Signature Center. Participating faculty come from the Schools of Science, Informatics, Medicine, and Dentistry. The Center is administered from the Department of Biology in the School of Science. Center administration consists of a Director, a Scientific Board to advise on scientific direction, and a Commercial Board to advise on technology transfer. For a complete description of the Center and its activities, see our website at www.regen.iupui.edu. Missions • Conduct multidisciplinary research aimed at understanding the mechanisms of natural regeneration, and translate the findings into regenerative therapies for tissues that fail to regenerate. • Provide graduate level academic training in regenerative biology and medicine. • Promote technology transfer. External Funding Sources CRBM faculty currently hold over $10M in research funding from a variety of Federal agencies and foundations: • NIH • NSF • NASA • W.M. Keck Foundation • Morton Cure Paralysis Foundation • American Health Assistance Foundation • American Cancer Society • Army Research Office.Item The IUPUI Center for HPV Research: Updates 2014-2015(Office of the Vice Chancellor for Research, 2015-04-17) Zimet, Gregory D.; Fortenberry, J. DennisBackground: Human papillomavirus (HPV) is a very common infection. High risk (HR) HPV types (particularly types 16 & 18) are causally implicated in many cancers, including cervical, anal, vaginal, vulvar, penile, and head and neck cancers. In an effort to address the problems associated with HPV infection and prevention, the Center for HPV Research at IUPUI (Zimet & Fortenberry, Co-Directors) fosters collaboration among investigators from multiple disciplines and departments at IUPUI, IU Bloomington, Purdue University, and University of Notre Dame. There currently are 32 faculty and 8 pre- and post-doctoral fellows who are members of the Center. The Center for HPV Research was established in July, 2012 with funds from the IUPUI Signature Center Initiative, the Department of Pediatrics, and the IU Simon Cancer Center. Over the past year, Center members had 6 external & internal grants funded, 5 additional grants submitted, 8 peer-reviewed articles published, and gave over 20 scientific conference and invited presentations. In this abstract we highlight a study representing a collaboration among 5 center members, with Dr. Marcia Shew as the lead and including an MPH student. Objectives: Most HR HPV infections do not progress to cancer, but progression is associated with persistent infection. HPV was previously thought to "clear" or persist, but newer studies suggest that HPV may be a latent virus that can be re-detected episodically. This study examined the persistence and/or redetection of HR HPV in young women recruited 6 years after identification of a HR HPV infection during their prior involvement in a longitudinal study of adolescent women. Methods: 30 women from the prior study (the Young Women’s Project) were recruited for 2 visits, 6 weeks apart. During Visit 1 they had a Pap test, HPV DNA testing, HPV serology, and were administered a semi-structured interview. During Visit 2, Pap test results were given, a self-swab for HPV testing was obtained, and a qualitative interview was administered. Results: 15 women had normal Pap test results, 2 were ASCUS, and 3 LGSIL. 12 women had a history of colposcopy for a previous abnormal Pap results and 4 had received treatment for cervical dysplasia. 26 of the women had HPV 16 in the original YWP study. 11 had HPV 16 redetected in the present study, including in 6 women who had apparently "cleared" the infection during the original YWP study. Conclusions: High risk HPV may not always (or ever) "clear" Persistent low viral levels may not be detectible. However, some HPV infections may be episodically detected if changes in immune function lead to increases in viral copies. Questions raised by this research include: 1) who is at risk for episodic detection?; 2) what factors are predictive of episodic detection?; 3) how likely is episodically-detect HR HPV to progress to cervical disease?; 4) what is the predictive value of a negative HPV DNA test?; and 5) what do we tell women with a positive HR HPV DNA screen if they have been sexually abstinent or with a life-long partner ... or if they have a new partner?Item The IUPUI Signature Center on Bio-Computing(Office of the Vice Chancellor for Research, 2010-04-09) Fang, Shiaofen; Mukhopadhyay, SnehasisBio-Computing is the discipline that integrates biomedical concepts and Computer Science techniques for collecting, managing, processing and analyzing large-scale biomedical data, as well as enables a deeper understanding of biological processes and medical procedures through modeling, simulation, and visualization. Bio-Computing emphasizes the algorithmic, computational, and software system issues arising from biomedical problems. It focuses on developing new, improved, specialized and customized Computer Science techniques and tools for computing related needs in life science applications that do not have ready-to-use solutions. The IUPUI Signature Center on Bio-Computing (SCBC) aims to act as a catalyst to provide BioComputing infrastructure and expertise for Indiana life science initiative. The specific mission is the following: • Bio-Computing Infrastructure: To develop cutting-edge bio-computing techniques and tools to establish an infrastructure as a framework to support life science applications. • Collaborative Projects: To actively engage in collaborative research projects, and maximize the impact of bio-computing in life science research and funding efforts. The scope of the projects supported by SCBC can be best described by the figure below:Item Transportation Active Safety Institute(Office of the Vice Chancellor for Research, 2010-04-09) Ainslie, Paul; Chen, Yaobin; Justiss, Michael; Koskie, Sarah; O’Connor, SeanSince its founding in February 2006, the mission of the Transportation Active Safety Institute (TASI) has been to advance the use of active safety systems to reduce vehicle crashes and save lives. TASI was one of 10 centers awarded IUPUI Signature Center funding in January, 2008. With core faculty drawn from ten departments representing eight schools, the Transportation Active Safety Institute (TASI) is a university-wide interdisciplinary center for advanced automotive-safety research and development on the IUPUI campus. Partnership with industry, government, and non-profit agencies ensures that university research activities complement existing technologies and address existing and future needs. TASI aims to provide a neutral forum for pre-competitive discussion and development of standards and test methodologies for establishing objective benefits of active-safety systems. TASI has established a driving simulator laboratory for research into driver behavior and for testing active-safety system performance. The state-of-the-art DriveSafety DS-600c Driving Simulator is providing a flexible and realistic driving environment for industry, government, and internally sponsored research. This reconfigurable platform allows TASI to test various sensors and driver interfaces, in order to determine effective and convenient solutions to challenges in enhancing safety. TASI held its third workshop, the International Workshop on Research in Active Safety Technology, August 10-11, 2009, in Indianapolis and is currently planning an international workshop on human factors for August 2010. TASI has established an active dialog with other vehicle safety centers around the world through our Global Academic Network for Active Safety.Item Transportation Active Safety Institute(Office of the Vice Chancellor for Research, 2011-04-08) Chen, Yaobin; Justiss, Michael; Koskie, Sarah; O’Connor, SeanSince its founding in February 2006, the mission of the Transportation Active Safety Institute (TASI) has been to advance the use of active safety systems to reduce vehicle crashes and save lives. TASI was one of 10 centers awarded IUPUI Signature Center funding (second round) in January, 2008. With core faculty drawn from ten departments representing eight schools at IUPUI, IUB and PUWL, the Transportation Active Safety Institute (TASI) is an interdisciplinary center for advanced transportation safety research and development on the IUPUI campus. Partnership with industry, government, and non-profit agencies ensures that university research activities complement existing technologies and address existing and future needs. TASI aims to provide a neutral forum for pre-competitive discussion and development of standards and test methodologies for establishing objective benefits of active-safety systems. TASI has established a driving simulator laboratory for research into driver behavior and for testing active safety system performance. The state-of-the-art DriveSafety DS-600c Driving Simulator is providing a flexible and realistic driving environment for industry, government, and internally sponsored research. This reconfigurable platform allows TASI to test various sensors and driver interfaces, in order to determine effective and convenient solutions to challenges in enhancing safety. Faculty members, research staff and graduate students have been working on several funded research projects such as human factors for semi-autonomous driving systems, intelligent human vehicle interfaces, real vehicle testing for crash-imminent braking system (autonomous braking system), distracted and impaired driving assessment, teen and older driver safety research, dealing with uncertainty in autonomous braking system, etc. TASI has also established an active dialog with other vehicle safety centers around the world through our “Global Academic Network for Active Safety.” Currently, global academic partners include Center for Automotive Research at the Ohio State University, National Advanced Driving Simulator at University of Iowa, University of Wisconsin, Tsinghua University in China, and Chalmers University of Technology in Sweden.