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Item Assessing a Longitudinal Educational Experience for Continuous Quality Improvement(Indiana University School of Medicine Education Day, 2024-04-26) Masseria, Anthony; Birnbaum, Deborah R.This presentation explores the use of assessment tools to promote adaptability and continuous quality improvement (CQI) in a large educational program. The Scholarly Concentrations Program is a statewide program complementing the core medical school curriculum and empowering students to delve into topics of personal interest. The pilot was launched with a “CQI” mindset, and after three years, a robust assessment plan is gathering feedback. While “building the plane as we fly it”, the program has grown from 100 students in its first year to over 400 in its third. A robust, longitudinal evaluation plan is critical. The intended goal is to use this program example to replicate it with other large educational programs anywhere.Item CHEMICAL GENOMICS CORE FACILITY(Office of the Vice Chancellor for Research, 2015-04-17) Chen, Lan; Wu, Li; Gunawan, Andrea; Zhang, Zhong-YinThe Chemical Genomics Core Facility (CGCF) is a shared facility of the IU Simon Cancer Center and IU School of Medicine. The mission of CGCF is to provide excellence and innovation in high throughput screening (HTS) and medicinal chemistry. The core is fully equipped for automated high throughput screening and modern chemical synthesis. We have a series of state-of-art liquid handling robots, a variety of plate readers capable of measuring absorbance, fluorescence, fluorescence polarization, luminescence, time-resolved fluorescence and AlphaLISA. We have recently acquired a high content analysis (HCA or HCS) platform, which greatly enhanced our capability in image based cellular assays. Facility for chemical synthesis includes different HPLCs, LC-MS, NMR, flushing column systems, peptide synthesizer and microwave reactor. Our compound collection is about 230,000 including structurally diverse, pharmacophore-rich drug-like compounds, known drugs and bioactives, natural products and their derivatives. As the first core facility of its kind to be established in an academic setting in Indiana, we have a proven record of providing screening expertise and synthetic service to researchers across Indiana and beyond. This shared facility enables investigators to discover small molecule tools for basic research, therapeutic development and diagnostic applications. The CGCF has been designed to be highly flexible in order to meet the needs of multiple users employing a range of assays. Facility staff works closely with each investigator through all stages of the drug discovery process, providing an opportunity for students and fellows to gain experience and training in high throughput screening and medicinal chemistry at the facility.Item Collaborative Research from the Center for Membrane Biosciences(Office of the Vice Chancellor for Research, 2010-04-09) Petrache, Horia I.; Justice, Matthew J.; Rogozea, Adriana L.; Patrusca, Daniela N.; Petrache, Irina; Wassall, Stephen R.; Siegel, Amanda; Murcia, Mike; Minner, Dan; Elmendorf, Jeffrey S.; Tackett, Lixuan; Naumann, Christoph A.The Center for Membrane Biosciences has been facilitating new research activities between the IUPUI School of Science and IU School of Medicine in the structure, biochemistry, and physiology of biological membranes. Results from two projects resulting from these collaborations are presented. Project 1: Ceramides are sphingolipids involved in the development of lung alveolar cell apoptosis (programmed death) and possibly in the clearance of apoptotic cells by alveolar macrophages. We use a combination of molecular and cellular methods to determine the effect of ceramides on the ability of alveolar macrophages to engulf apoptotic cells. Engulfment experiments of labeled apoptotic Jurkat cells were performed with rat alveolar macrophages (AM) obtained via bronchoalveolar lavage. AM were treated with various ceramide species and efferocytosis was quantified by flow cytometry. Using small-angle X-ray scattering and solid state 2H NMR we determined how ceramides (C6:0, C18:1) affect the molecular organization and the physical properties of model membranes. These studies can lead to a better understanding of the molecular mechanisms responsible for apoptotic cell clearance. If the clearance process is impaired, apoptotic cells may progress to secondary necrosis, resulting in release of harmful cellular contents and tissue inflammation. Project 2: Highly-photostable quantum dots (QD) conjugated to lipids or antibodies can be utilized to explore changes in compartmentalization of the plasma membrane due to hyperinsulinemia using wide field single molecule fluorescence microscopy. Protocols describing the bio-inertness and monovalent binding of QDs to antibodies are outlined, as well as use of confocal fluorescence correlation spectroscopy to determine colloidal stability of CdSe/ZnS QDs in aqueous solution. Tracking experiments on QD-conjugated to transferrin receptors in healthy and insulin-resistant adipocytes detect changes in membrane compartmentalization. The impact of chromium picolinate on receptor mobility was also investigated.Item Re-thinking recruitment for community-based research using service design methods: CLIC*: Communicating Life in Our Community/Communicando la vida en nuestra comunidad(Office of the Vice Chancellor for Research, 2012-04-13) Sanematsu, HelenIn summer 2011 the IU School of Medicine along with faculty from the Herron School of Art and Design embarked upon a study to learn more about the lives of Latino Adolescents and how to better engage them in research. While Communicating Life in Our Community / Communicando la vida en nuestra comunidad (CLIC) was developed to assist with research project recruitment in the Near West Side, the methods used in the study also point to a way to start a bi-directional, mutually beneficial dialogue between residents of Indianapolis and the School of Medicine. In effect, the CLIC study methods extended the scope of the project and built on its potential to extend to overall community development. Using methodology from design research, participants told the story of their daily lives with photography, video, blogs, and drawings. Through such activities, community participants in CLIC and researchers together started to develop an infrastructure for ongoing, bi-directional and mutually beneficial engagement.Item The History of Medicine Collection at Ruth Lilly Medical Library(Midwest Archives Conference, 2022-10-01) Pieczko, Brandon T.; Ruth Lilly Medical Library, School of MedicineThe History of Medicine Collection is a special collection unit within the Ruth Lilly Medical Library located on the campus of Indiana University–Purdue University Indianapolis. As part of the Indiana University School of Medicine—the largest MD-granting medical school in the United States by enrollment—the mission of the History of Medicine Collection is to support the research, learning, and educational success of Indiana University students, faculty, and community members by collecting, preserving, interpreting, and providing access to unique materials documenting the history of medicine; medical education, training, research, and practice; and health and disease treatment and prevention in the state of Indiana and beyond.Item Women's Wellness on Wheels (WOW) Bus Program(Office of the Vice Chancellor for Research, 2012-04-13) Reid, TishaThe IU Center of Excellence (COE) a program of the IU School of Medicine and the Department of OBGYN, is designed to convene partners in the state toward the fulfillment of our mission and vision, in improving the health of Indiana women. The Women's Wellness on Wheels (WOW) Bus Program is a mechanism utilized statewide to provide health education and screenings targeted to rural and underserved Indiana women. Through this community outreach, WOW is designed to drive more women into local health care, encouraging them to build relationships with providers close to their homes, thereby creating the patient-provider partnership required for optimum health. Inclusive in the WOW Bus Program is our education/training component, by which health care students learn about the challenges in finding local health care and resources for diverse communities. In this way we hope to increase the number of health care providers considering practice in rural and underserved communities and forge partnerships between women and their local communities to address women's health issues at the local level.