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Item 11039 Indiana CTSI High-School STEM Summer Research Program: Future opportunities from a 2020 virtual program(Cambridge University Press, 2021) Sanders, Elmer; Cruz, Leigh-Ann; Speidell, Emily; Schnabel, Rose; Balaji, Adhitya; Hogarth, Elise; Miller, Jade; Vaides, Sofia; Allen, Matthew R.; Medicine, School of MedicineABSTRACT IMPACT: The Indiana Clinical and Translational Sciences Institute K-12 STEM Outreach Program’s pivoted to a virtual program in summer 2020 which yielded novel approaches that could be retained in future years to extend the reach/impact of our pipeline program. OBJECTIVES/GOALS: Provide students with a meaningful and safe research experience during the COVID Pandemic. Develop new modules and approaches that could be delivered virtually. Engage students from communities that were not possible in previous years when in person meetings were required. METHODS/STUDY POPULATION: The program has historically supported over 100 high school students per year in a summer research internship for the last 5 years. Students are placed with academic research mentors in various Schools and Departments across the IUPUI campus, and also with industry laboratories. COVID-related restrictions required development of 100% virtual program. Key aspects of the virtual program included: cohort-based research mentor assignments with 1-4 mentees matched per research mentor, research projects that could be conducted virtually, heavy engagement of high-school teachers to facilitate the research experience with cohorts of mentees, a more rigorous virtual seminar series that included new modules such as COVID-specific programming and thus enhancing public education about COVID. RESULTS/ANTICIPATED RESULTS: The program served 130 students in summer 2020. We were able to recruit new faculty and industry mentors involved in data science research. As a result, we have now increased our mentor pool to serve more students in the future. Because student participation was virtual, we were able to accept students from further distances (up to 120 miles away) across the state. We were also able to accept local economically disadvantaged students that may have not been able to participate because of lack of reliable transportation. A positive unanticipated outcome was that mentees relationships with the mentors was established virtually thus increasing the potential for students to remain engaged in their research. DISCUSSION/SIGNIFICANCE OF FINDINGS: Adapting to a virtual platform provided research experience to high school students during a time when traditional approaches were not possible. Given some research experiences do not require in-person activities, this newly established model could be used moving forward to allow more statewide engagement in research experiences.Item 2023 Read Aloud Indiana(Indiana Library Federation, 2023) Indiana Library FederationItem 4539 Building a Translational Science pipeline: The Indiana CTSI STEM K-12 Program(Cambridge University Press, 2020-07-29) Sanders, Elmer; Barth, Vanessa; Cruz, Leigh-Ann; Sherrer, Ilesha; Olson, Jacob; Speidell, Emily; Solis, Elvia; Harrison, Sharon; Hinshaw, Amy; McAteer, James A.; Anatomy, Cell Biology and Physiology, School of MedicineOBJECTIVES/GOALS: Develop strong network of science teachers interested in promoting scientific research to their students. Place students in an immersive summer research internship that, when possible, matches their career interests. Expose students to the numerous career paths within the STEM field. METHODS/STUDY POPULATION: The program recruits socio-economically disadvantaged students and provides them a stipend, and also accepts students who can participate unpaid. Local school teachers are engaged in a summer fellowship to learn biotechnologies and research. In Spring these teachers help recruit students and during the subsequent Fall help students with college and scholarship applications. Students are placed in a variety of laboratories within the Schools of Medicine, Science, Dentistry, Public Health, Informatics, Health and Human Sciences, Engineering and Technology, especially in biomedical engineering. Students are also placed in industry laboratories such as Eli Lilly and the Indiana Bioscience Research Institute. Long-term program follow-up is done through post-internship surveys to assess impact on graduate and professional school admission. RESULTS/ANTICIPATED RESULTS: Since the Indiana CTSI was established in 2008, 872 students have participated in the summer internship. 71% of past interns are underrepresented minorities in science or classified as disadvantaged by NIH criteria. 17% of students interned during grade 10, 72% during grade 11, and 11% during grade 12. 21% of students engage in the program for more than one year. 100% of past interns are currently enrolled in or have graduated college. Over 60% of those with a bachelors degree proceed to graduate and professional schools and over 80% stay in STEM related fields. These rates are equal for interns from underrepresented minorities or those classified as disadvantaged by NIH criteria. DISCUSSION/SIGNIFICANCE OF IMPACT: Students engaged in the Indiana CTSI STEM program are progressing through the translational science pipeline based on their graduating from college and remaining in the STEM field.