Browsing by Subject "Heterogeneous nuclear ribonucleoprotein (hnRNP)"

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    FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing
    (American Society for Biochemistry and Molecular Biology, 2018-06-29) Du, Jianguang; Wang, Qun; Ziegler, Steven F.; Zhou, Baohua; Microbiology and Immunology, School of Medicine
    FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes. We report here that FOXP3 associates with heterogeneous nuclear ribonucleoprotein (hnRNP) F through the exon 2-encoded region of FOXP3 and the second quasi-RNA recognition motif (qRRM) of hnRNPF. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing. Furthermore, overexpression of mouse hnRNPF in in vitro-differentiated regulatory T cells (Tregs) reduced their suppressive function. Thus, our studies identify a novel mechanism by which FOXP3 regulates mRNA alternative splicing to modulate the function of regulatory T cells.