Browsing by Subject "Hematopoietic Stem and Progenitor Cells"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    The Brain: Is it a Next Frontier to Better Understand the Regulation and Control of Hematopoiesis for Future Modulation and Treatment?
    (Springer, 2021-08) Broxmeyer, Hal E.; Yoder, Karmen K.; Wu, Yu-Chien; Hutchins, Gary D.; Cooper, Scott H.; Farag, Sherif S.; Microbiology and Immunology, School of Medicine
    We wish to suggest the possibility there is a link between the brain and hematopoiesis in the bone marrow and that in the future it may be possible to use such information for better understanding of the regulation of hematopoiesis, and for efficacious treatment of hematopoietic disorders.
  • Thumbnail Image
    Item
    Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?
    (Springer Nature, 2020-11-03) Broxmeyer, Hal E.; Liu, Yan; Kapur, Reuben; Orschell, Christie M.; Aljoufi, Arafat; Ropa, James P.; Trinh, Thao; Burns, Sarah; Capitano, Maegan L.; Microbiology and Immunology, School of Medicine
    There is an ongoing shift in demographics such that older persons will outnumber young persons in the coming years, and with it age-associated tissue attrition and increased diseases and disorders. There has been increased information on the association of the aging process with dysregulation of hematopoietic stem (HSC) and progenitor (HPC) cells, and hematopoiesis. This review provides an extensive up-to date summary on the literature of aged hematopoiesis and HSCs placed in context of potential artifacts of the collection and processing procedure, that may not be totally representative of the status of HSCs in their in vivo bone marrow microenvironment, and what the implications of this are for understanding aged hematopoiesis. This review covers a number of interactive areas, many of which have not been adequately explored. There are still many unknowns and mechanistic insights to be elucidated to better understand effects of aging on the hematopoietic system, efforts that will take multidisciplinary approaches, and that could lead to means to ameliorate at least some of the dysregulation of HSCs and HPCs associated with the aging process.