Browsing by Subject "Healthy aging"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Apolipoprotein E ɛ4-related effects on cognition are limited to the Alzheimer's disease spectrum
    (Springer, 2022) Fernández, Alberto; Vaquero, Lucía; Bajo, Ricardo; Zuluaga, Pilar; ADNI–Alzheimer’s Disease Neuroimaging Initiative; Radiology and Imaging Sciences, School of Medicine
    Whether the deleterious effects of APOE4 are restricted to the Alzheimer's disease (AD) spectrum or cause cognitive impairment irrespectively of the development of AD is still a matter of debate, and the focus of this study. Our analyses included APOE4 genotype, neuropsychological variables, amyloid-βeta (Aβ) and Tau markers, FDG-PET values, and hippocampal volumetry data derived from the healthy controls sample of the ADNI database. We formed 4 groups of equal size (n = 30) based on APOE4 carriage and amyloid-PET status. Baseline and follow-up (i.e., 48 months post-baseline) results indicated that Aβ-positivity was the most important factor to explain poorer cognitive performance, while APOE4 only exerted a significant effect in Aβ-positive subjects. Additionally, multiple regression analyses evidenced that, within the Aβ-positive sample, hippocampal volumetry explained most of the variability in cognitive performance for APOE4 carriers. These findings represent a strong support for the so-called preclinical/prodromal hypothesis, which states that the reported differences in cognitive performance between healthy carriers and non-carriers are mainly due to the APOE4's capability to increase the risk of AD. Moreover, our results reinforce the notion that a synergistic interaction of Aβ and APOE4 elicits a neurodegenerative process in the hippocampus that might be the main cause of impaired cognitive performance.
  • Thumbnail Image
    Item
    Healthy Aging Brain Care Monitor Caregiver Version (HABC-M CG): An Informant-Based Screening Tool for Post-Intensive Care Syndrome (PICS)
    (American Association of Critical-Care Nurses, 2022) Wang, Sophia; Jawed, Yameena; Perkins, Anthony; Gao, Sujuan; Seyffert, Sarah; Khan, Sikandar; Boustani, Malaz; Khan, Babar; Psychiatry, School of Medicine
    Background: Cognitive impairment is common in intensive care unit survivors, pointing to the potential utility of a caregiver-based tool to screen for post-intensive care syndrome. Objective: To validate the Healthy Aging Brain Care Monitor, Caregiver Version (HABC-M CG), as a caregiver-based tool to screen for post-intensive care syndrome. Methods: A total of 116 patients who survived a stay in the intensive care unit completed standardized assessments of cognition, psychological symptoms, and physical functioning, and their caregivers completed the HABC-M CG. The Cronbach α was used to measure the internal consistency of the scale items. Validity of the HABC-M CG versus comparison tests was measured using the Spearman rank correlation. Generalized linear models were used to adjust for age, sex, and education level. Results: The total scale and all subscales of the HABC-M CG showed excellent internal consistency (Cronbach α = 0.88-0.93). Scores on the psychological subscale correlated with standardized measures of depressive symptoms (Spearman ρ = 0.58). Scores on the cognitive subscale correlated with the Mini-Mental State Examination score (Spearman ρ = -0.33). Scores on the functional subscale correlated with scores on the Physical Self-Maintenance Scale (Spearman ρ = -0.36). Conclusion: The HABC-M CG is a valid informant-based clinical tool for the assessment of symptoms of post- intensive care syndrome.
  • Thumbnail Image
    Item
    Healthy Aging Brain Care Monitor Caregiver Version (HABC-M CG): An Informant-Based Screening Tool for Post-Intensive Care Syndrome (PICS)
    (American Association of Critical-Care Nurses, 2022) Wang, Sophia; Jawed, Yameena; Perkins, Anthony; Gao, Sujuan; Seyffert, Sarah; Khan, Sikandar; Boustani, Malaz; Khan, Babar; Psychiatry, School of Medicine
    Background: Cognitive impairment is common in intensive care unit survivors, pointing to the potential utility of a caregiver-based tool to screen for post-intensive care syndrome. Objective: To validate the Healthy Aging Brain Care Monitor, Caregiver Version (HABC-M CG), as a caregiver-based tool to screen for post-intensive care syndrome. Methods: A total of 116 patients who survived a stay in the intensive care unit completed standardized assessments of cognition, psychological symptoms, and physical functioning, and their caregivers completed the HABC-M CG. The Cronbach α was used to measure the internal consistency of the scale items. Validity of the HABC-M CG versus comparison tests was measured using the Spearman rank correlation. Generalized linear models were used to adjust for age, sex, and education level. Results: The total scale and all subscales of the HABC-M CG showed excellent internal consistency (Cronbach α = 0.88-0.93). Scores on the psychological subscale correlated with standardized measures of depressive symptoms (Spearman ρ = 0.58). Scores on the cognitive subscale correlated with the Mini-Mental State Examination score (Spearman ρ = -0.33). Scores on the functional subscale correlated with scores on the Physical Self-Maintenance Scale (Spearman ρ = -0.36). Conclusion: The HABC-M CG is a valid informant-based clinical tool for the assessment of symptoms of post- intensive care syndrome.