Browsing by Subject "Genetic linkage"

Now showing 1 - 3 of 3
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    Genetic strategies to detect genes involved in alcoholism and alcohol-related traits
    (The National Institute on Alcohol Abuse and Alcoholism, 2002) Dick, Danielle M.; Foroud, Tatiana; Medical and Molecular Genetics, School of Medicine
    Researchers are using a variety of sophisticated approaches to identify genes that contribute to the development of alcoholism in humans or influence other alcohol-related traits. These strategies include linkage approaches, which can identify broad chromosomal regions that are likely to contain genes predisposing to the disorder, and association approaches, which test the association between a particular marker allele and a specific outcome. Animal studies using diverse strategies can also help identify genes or DNA regions that influence alcohol-related traits in humans. The results of these analyses are likely to have implications for fields such as genetic counseling, gene therapy, and pharmacogenetics.
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    Is there a genetic relationship between alcoholism and depression?
    (The National Institute on Alcohol Abuse and Alcoholism, 2002) Nurnberger, John I., Jr.; Foroud, Tatiana; Flury, Leah; Meyer, Eric T.; Wiegand, Ryan; Medical and Molecular Genetics, School of Medicine
    The Collaborative Study on the Genetics of Alcoholism (COGA) seeks to identify genes contributing to alcoholism and related traits (i.e., phenotypes), including depression. Among alcoholic subjects the COGA study found an increased prevalence of depressive syndrome (i.e., depression that may or may not occur in conjunction with increased drinking). This combination of alcoholism and depression tends to run in families. Comorbid alcoholism and depression occurred substantially more often in first-degree relatives of COGA participants with alcoholism than in relatives of control participants. Based on these data, COGA investigators defined three phenotypes—“alcoholism,” “alcoholism and depression,” and “alcoholism or depression”—and analyzed whether these phenotypes were linked to specific chromosomal regions. These analyses found that the “alcoholism or depression” phenotype showed significant evidence for genetic linkage to an area on chromosome 1. This suggests that a gene or genes on chromosome 1 may predispose some people to alcoholism and others to depression (which may be alcohol induced).
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    Linkage analysis in a large kindred with autosomal dominant transmission of polyglandular autoimmune disease type II (Schmidt syndrome)
    (Wiley, 1984-05-18) Butler, Merlin G.; Hodes, M.E.; Conneally, P.M.; Biegel, Angenieta A.; Wright, James C.; Department of Medical and Molecular Genetics, IU School of Medicine
    Schmidt syndrome (PGA syndrome type II) is a rare condition characterized by polyglandular failure. It is an autosomal dominant trait with variable expressivity that was inherited over four generations in an Indiana kindred. Association of HLA-B8 has been reported with Schmidt syndrome. Our proband is a 12-year-old boy with Addison disease, insulin dependent diabetes mellitus (IDDM), and vitiligo. Two of his eight sibs had either IDDM (sister) or vitiligo and hyperthyroidism (brother). His mother had hypothyroidism. Seven members of earlier generations apparently were also affected. We obtained peripheral blood for HLA and genetic analysis from 21 relatives in a family with 8 Schmidt syndrome individuals in three generations. HLA studies on 15 affected and unaffected relatives showed only 2 of 7 persons with B8-containing haplotypes. Therefore, no association exists between the B8-containing haplotype and the syndrome. We identified informative marker loci. No evidence for linkage of the Schmidt locus to any of the 14 markers was found and close linkage to esterase D and adenylate kinase and possibly properdin factor B was excluded.