Browsing by Subject "Genetic Research"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    The emerging genomics and systems biology research lead to systems genomics studies
    (Springer (Biomed Central Ltd.), 2014) Yang, Mary Qu; Yoshigoe, Kenji; Yang, William; Tong, Weida; Qin, Xiang; Dunker, A. Keith; Chen, Zhongxue; Arbania, Hamid R.; Liu, Jun S.; Niemierko, Andrzej; Yang, Jack Y.; Department of Biochemistry and Molecular Biology, IU School of Medicine
    Synergistically integrating multi-layer genomic data at systems level not only can lead to deeper insights into the molecular mechanisms related to disease initiation and progression, but also can guide pathway-based biomarker and drug target identification. With the advent of high-throughput next-generation sequencing technologies, sequencing both DNA and RNA has generated multi-layer genomic data that can provide DNA polymorphism, non-coding RNA, messenger RNA, gene expression, isoform and alternative splicing information. Systems biology on the other hand studies complex biological systems, particularly systematic study of complex molecular interactions within specific cells or organisms. Genomics and molecular systems biology can be merged into the study of genomic profiles and implicated biological functions at cellular or organism level. The prospectively emerging field can be referred to as systems genomics or genomic systems biology. The Mid-South Bioinformatics Centre (MBC) and Joint Bioinformatics Ph.D. Program of University of Arkansas at Little Rock and University of Arkansas for Medical Sciences are particularly interested in promoting education and research advancement in this prospectively emerging field. Based on past investigations and research outcomes, MBC is further utilizing differential gene and isoform/exon expression from RNA-seq and co-regulation from the ChiP-seq specific for different phenotypes in combination with protein-protein interactions, and protein-DNA interactions to construct high-level gene networks for an integrative genome-phoneme investigation at systems biology level.
  • Thumbnail Image
    Item
    Public Attitudes Regarding Genetic Research: Summary of Methods and Findings
    (2009-10-09T21:31:24Z) Survey Research Center at IUPUI; Wolf, James G.
    The Indiana University School of Medicine Center for Bioethics Program in Predictive Health Ethics Research commissioned the Survey Research Center at IUPUI to conduct a random-digit-dial telephone survey of Indiana residents in an effort to determine the following: the public’s perception of its own understanding of medical and genetic research, public confidence in medical and genetic research, the likelihood of participation if asked, and the sense of public control of genetic research. The following report details the main findings from this research.