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Browsing by Subject "Gene transcription"
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Item Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene(Wolters Kluwer, 2023) Nanamatsu, Azuma; Micanovic, Radmila; Khan, Shehnaz; El-Achkar, Tarek M.; LaFavers, Kaice A.; Medicine, School of Medicine*Serum uromodulin levels are higher in healthy female participants than healthy male participants. *Serum uromodulin levels in participants with normal kidney function do not correlate with eGFR but do correlate with body mass index. *Estrogen increases uromodulin production, likely because of noncanonical and half estrogen response elements in the UMOD gene.Item HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation(National Academy of Science, 2022) Cheung, Ka Lung; Jaganathan, Anbalagan; Hu, Yuan; Xu, Feihong; Lejeune, Alannah; Sharma, Rajal; Caescu, Cristina I.; Meslamani, Jamel; Vincek, Adam; Zhang, Fan; Lee, Kyung; Zaware, Nilesh; Qayum, Amina Abdul; Ren, Chunyan; Kaplan, Mark H.; He, John Cijiang; Xiong, Huabao; Zhou, Ming-Ming; Microbiology and Immunology, School of MedicineSignificanceSTAT3 (signal transducer and activator of transcription 3) is a master transcription factor that organizes cellular responses to cytokines and growth factors and is implicated in inflammatory disorders. STAT3 is a well-recognized therapeutic target for human cancer and inflammatory disorders, but how its function is regulated in a cell type-specific manner has been a major outstanding question. We discovered that Stat3 imposes self-directed regulation through controlling transcription of its own regulator homeodomain-interacting protein kinase 2 (Hipk2) in a T helper 17 (Th17) cell-specific manner. Our validation of the functional importance of the Stat3-Hipk2 axis in Th17 cell development in the pathogenesis of T cell-induced colitis in mice suggests an approach to therapeutically treat inflammatory bowel diseases that currently lack a safe and effective therapy.Item Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function(Springer Nature, 2019-12) Chen, Yandan; Yao, Chunxu; Teng, Yincheng; Jiang, Rongzhen; Huang, Xinxin; Liu, Sheng; Wan, Jun; Broxmeyer, Hal E.; Guo, Bin; Microbiology and Immunology, School of Medicine