Browsing by Subject "GLP"

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    Vaccine for Diabetes-Where Do We Stand?
    (MDPI, 2022-08-22) Chellappan, Dinesh Kumar; Bhandare, Richie R.; Shaik, Afzal B.; Prasad, Krishna; Suhaimi, Nurfatihah Azlyna Ahmad; Yap, Wei Sheng; Das, Arpita; Banerjee, Pradipta; Ghosh, Nandini; Guith, Tanner; Das, Amitava; Balakrishnan, Sarannya; Candasamy, Mayuren; Mayuren, Jayashree; Palaniveloo, Kishneth; Gupta, Gaurav; Singh, Sachin Kumar; Dua, Kamal; Surgery, School of Medicine
    Diabetes is an endocrinological disorder with a rapidly increasing number of patients globally. Over the last few years, the alarming status of diabetes has become a pivotal factor pertaining to morbidity and mortality among the youth as well as middle-aged people. Current developments in our understanding related to autoimmune responses leading to diabetes have developed a cause for concern in the prospective usage of immunomodulatory agents to prevent diabetes. The mechanism of action of vaccines varies greatly, such as removing autoreactive T cells and inhibiting the interactions between immune cells. Currently, most developed diabetes vaccines have been tested in animal models, while only a few human trials have been completed with positive outcomes. In this review, we investigate the undergoing clinical trial studies for the development of a prototype diabetes vaccine.