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Browsing by Subject "Fine needle aspiration"
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Item Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates(Frontiers Media, 2021-04-16) Su, Jing; Huang, Lynn S.; Barnard, Ryan; Parks, Graham; Cappellari, James; Bellinger, Christina; Dotson, Travis; Craddock, Lou; Prakash, Bharat; Hovda, Jonathan; Clark, Hollins; Petty, William Jeffrey; Pasche, Boris; Chan, Michael D.; Miller, Lance D.; Ruiz, Jimmy; Biostatistics, School of Public HealthThe Comprehensive, Computable NanoString Diagnostic gene panel (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Small Cell Lung Cancer (NSCLC) derived from public transcriptomic data which establish a highly robust and accurate subtyping system. The C2Dx demonstrates supreme performance on the NanoString platform using microgram-level FNA samples and has excellent portability to frozen tissues and RNA-Seq transcriptomic data. This workflow shows great potential for research and the clinical practice of cancer molecular diagnosis.Item Diagnosis and Management of Pancreatic Cysts: A Comprehensive Review of the Literature(MDPI, 2023-02-02) Singh, Ritu R.; Gopakumar, Harishankar; Sharma, Neil R.; Medicine, School of MedicineThe prevalence of pancreatic cysts has been rising due to the widespread use of cross-sectional imaging (CT scan and MRI) of the abdomen. While most pancreatic cysts are benign and do not require treatment or surveillance, a significant minority are premalignant and rarely malignant. The risk stratification of these lesions is not straightforward, and individual risk assessment, cyst size, distribution, and alarming morphologic features (when present) can guide the next steps in management. Neoplastic pancreatic cysts are mucinous or non-mucinous. Endoscopic ultrasound with fine-needle aspiration is often required to classify pancreatic cysts into mucinous and non-mucinous cysts and to assess the malignant potential. Advances in endoscopic techniques (confocal laser endomicroscopy, microforceps biopsy) can provide a definitive diagnosis of pancreatic cysts in some cases; however, the use of these techniques involves a higher risk of adverse events.