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Item Time to First-Line ART Failure and Time to Second-Line ART Switch in the IeDEA Pediatric Cohort(Wolters Kluwer, 2018-06-01) Wools-Kaloustian, Kara; Marete, Irene; Ayaya, Samuel; Sohn, Annette H.; Nguyen, Lam Van; Li, Shanshan; Leroy, Valériane; Musick, Beverly S.; Newman, Jamie E.; Edmonds, Andrew; Davies, Mary-Ann; Tanoh Eboua, François; Obama, Marie-Thérèse; Yotebieng, Marcel; Sawry, Shobna; Mofenson, Lynne M.; Yiannoutsos, Constantin T.; Medicine, School of MedicineBACKGROUND: Globally, 49% of the estimated 1.8 million children living with HIV are accessing antiretroviral therapy (ART). There are limited data concerning long-term durability of first-line ART regimens and time to transition to second-line. METHODS: Children initiating their first ART regimen between 2 and 14 years of age and enrolled in one of 208 sites in 30 Asia-Pacific and African countries participating in the Pediatric International Epidemiology Databases to Evaluate AIDS consortium were included in this analysis. Outcomes of interest were: first-line ART failure (clinical, immunologic, or virologic), change to second-line, and attrition (death or loss to program ). Cumulative incidence was computed for first-line failure and second-line initiation, with attrition as a competing event. RESULTS: In 27,031 children, median age at ART initiation was 6.7 years. Median baseline CD4% for children ≤5 years of age was 13.2% and CD4 count for those >5 years was 258 cells per microliter. Almost all (94.4%) initiated a nonnucleoside reverse transcriptase inhibitor; 5.3% a protease inhibitor, and 0.3% a triple nucleoside reverse transcriptase inhibitor-based regimen. At 1 year, 7.7% had failed and 14.4% had experienced attrition; by 5 years, the cumulative incidence was 25.9% and 29.4%, respectively. At 1 year after ART failure, 13.7% had transitioned to second-line and 11.2% had experienced attrition; by 5 years, the cumulative incidence was 31.6% and 25.9%, respectively. CONCLUSIONS: High rates of first-line failure and attrition were identified in children within 5 years after ART initiation. Of children meeting failure criteria, only one-third were transitioned to second-line ART within 5 years.Item What factors contribute to the Success and Failure of Latino Outreach and Information Programs in Indianapolis?(Office of the Vice Chancellor for Research, 2015-04-17) Sosa, Carlos; Hook, Sara AnneAbstract Many social service, educational, and commercial entities make a concerted effort to engage local Latino communites through various programs. They seek to create awareness for their service or products, or offer a service needed by these communities. Many do so in isolation, and do not collaborate with organization who may serve/target similar audiences or communities. Information often does not reach the intended communities and program participation is low in many cases. They may need a better way to engage these communities. One way to improve participation may be to understand more about the targeted audience—to paint a clearer picture of the local Latino communities. There is a need to create a dataset that helps both the Latino communities and will also assist community organizations to interact with the Latino communities. Exactly what that looks like is the focus of this research—to see what currently exists and to determine resources on which to elaborate. Working with the Indiana State Bar Association, our group intends to explore a project related to immigration law. Specifically, the many instances of misinformation provided by individuals who engage in the Unauthorized Practice of Law in Indiana. There is a need to focus on the role that technology will play in BOTH acquiring info and delivering information to help protect members of the Latino communities for whom correct information is vital to their remaining in the U.S. In order to provide various communities, corporations, organizations, goverment agencies with a more accurate picture of the state of their local Latino communities, we need to go out into the communities and begin to quantify certain information. Current available information is largely based on census data (grossly under-reported) and anecdotal info. The importance of providing information that goes beyond anecdotal information is high. Facts about these communities is in demand. This will be useful to local corporations, educational and social service orgs, community churches and programs. I also plan to demonstrate the importance of well-designed graphic elements (typography, charts, symbols, illustrations) in the delivery of informatic data. Data acquired during this process can come from both primary and secondary sources. There is a strong need to collaborate with several entities (academic, commercial)to understand how to acquire, analize and digest the data. This is a proposal to present consumer, social and cultural behavior of these communities in a deliverable package that is easy to access, present and understand. The resulting information should ultimately serve to improve the lives of these communities.