Browsing by Subject "Exposure"

Now showing 1 - 3 of 3
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    Comparing Newborn Outcomes After Prenatal Exposure to Individual Antidepressants: a retrospective cohort study
    (Wiley, 2021) Marks, Claire; Silvola, Rebecca; Teal, Evgennia; Quinney, Sara K,; Haas, David M.; Obstetrics and Gynecology, School of Medicine
    Objective: To compare associations between individual antidepressants and newborn outcomes. Design: Retrospective cohort study. Setting: Deliveries in a large, US medical system. Population: Women who received at least one antidepressant prescription 3 months prior to conception through delivery. Methods: Eligible women had maternal characteristics and newborn outcomes extracted from medical record data. Exposure was defined by the timing of the prescription during pregnancy. Main outcome measures: Newborn outcomes (any adaptation syndrome, neonatal intensive care unit (NICU) admission) were analyzed for each antidepressant and compared using standard statistics and multivariable regression compared to exposure to bupropion. Odds of outcomes based on timing of exposure were also explored. Results: A total of 3,694 women were analyzed. Rates of any adaptation syndrome (p < 0.001), NICU admission (p < 0.001), and transient tachypnea of newborn (TTN) (p = 0.006) were significantly different between drugs. Infants exposed to duloxetine had the highest rates of NICU admissions (39.6%) and adaptation syndromes (15.1%). Venlafaxine-exposed infants had the highest rates of TTN (18.2%). Controlling for maternal age, race, insurance, and gestational age at delivery, early pregnancy antidepressant exposure was associated with adaptation syndrome and NICU admission for both duloxetine (adjusted odds ratio (aOR) 2.31 [95% Confidence Interval (CI) 1.11-4.80] and aOR 2.47 [95% CI 1.40-4.34], respectively) and escitalopram (aOR 1.72 [95% CI 1.09-2.70] and aOR 1.64 [95% CI 1.21-2.22], respectively). Exposure in the third trimester was associated with any adaptation syndrome for citalopram, duloxetine, escitalopram, fluoxetine, sertraline, and venlafaxine and NICU admission for bupropion, citalopram, duloxetine, escitalopram, and fluoxetine. Conclusion: Duloxetine and escitalopram appear to have the strongest associations with any adaptation syndrome and NICU admission whereas bupropion and sertraline tended to have among the lowest risks of these outcomes. These results can help providers and patients discuss choice of individual antidepressant drugs during pregnancy.
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    Seroprevalence of SARS-CoV-2 Antibodies Among Healthcare Workers With Differing Levels of COVID-19 Patient Exposure
    (Cambridge University Press, 2020-08-03) Hunter, Benton R.; Dbeibo, Lana; Weaver, Christopher; Beeler, Cole; Saysana, Michele; Zimmerman, Michelle; Weaver, Lindsay; Emergency Medicine, School of Medicine
    Healthcare employees were tested for antibodies against SARS-CoV-2. Among 734 employees, the prevalence of SARS-CoV-2 antibodies was 1.6%. Employees with heavy COVID-19 exposure had similar antibody prevalence as those with limited or no exposure. Guidelines for PPE use seem effective for preventing COVID-19 infection in healthcare workers.
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    Unequal access: Tobacco Retail in the Indianapolis Metro Area
    (The Polis Center, Indiana University at Indianapolis, 2017-07) Comer, Karen; Davila, Kelly; Hollon, Deb; Nowlin, Matt
    Retail access to various smoking products is an important consideration when discussing community action to improve a community’s health. Studies show that tobacco outlet density and proximity are linked to tobacco use–particularly in poor areas. We used socioeconomic data culled from the SAVI community information system to examine the density and proximity of tobacco outlets relative to vulnerable communities in Marion County. The report serves as a companion piece to the IU Richard M. Fairbanks School of Public Health’s September 2016 Report on the Tobacco Epidemic in Marion County and Indiana.