Browsing by Subject "Eosinophilic gastritis"

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    Impressions and aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field
    (Elsevier, 2022) Rothenberg, Marc E.; Hottinger, Shawna K. B.; Gonsalves, Nirmala; Furuta, Glenn T.; Collins, Margaret H.; Talley, Nicholas J.; Peterson, Kathryn; Menard-Katcher, Calies; Smith, Macie; Hirano, Ikuo; Genta, Robert M.; Chehade, Mirna; Gupta, Sandeep K.; Spergel, Jonathan M.; Aceves, Seema S.; Dellon, Evan S.; Pediatrics, School of Medicine
    The US Food and Drug Administration hosted a workshop on July 21, 2021, to discuss the disease characteristics, natural history, and end points to assess treatment benefit in patients with eosinophilic gastrointestinal disorders (EGIDs) beyond eosinophilic esophagitis (EoE). Notably, EGIDs beyond EoE, such as eosinophilic gastritis, eosinophilic enteritis, and eosinophilic colitis, herein referred to as non-EoE EGIDs, are understudied relative to EoE. This workshop provided a forum for open discussion among stakeholders-medical professionals (including their societies and research groups), Food and Drug Administration representatives, an industry representative, and a patient representative-to facilitate drug development. Experts in many disciplines related to EGIDs, including allergy, immunology, epidemiology, gastroenterology, and pathology, and both adult and pediatric clinicians contributed. Herein, we discuss some of the insights of the material presented at the meeting and present perspectives on moving the field forward toward drug approval.
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    Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort
    (Wolters Kluwer, 2022) Hirano, Ikuo; Collins, Margaret H.; King, Eileen; Sun, Qin; Chehade, Mirna; Abonia, J. Pablo; Bonis, Peter A.; Capocelli, Kelly E.; Dellon, Evan S.; Falk, Gary W.; Gonsalves, Nirmala; Gupta, Sandeep K.; Leung, John; Katzka, David; Menard-Katcher, Paul; Khoury, Paneez; Klion, Amy; Mukkada, Vincent A.; Peterson, Kathryn; Shoda, Tetsuo; Rudman-Spergel, Amanda K.; Spergel, Jonathan A.; Yang, Guang-Yu; Rothenberg, Marc E.; Aceves, Seema S.; Furuta, Glenn T.; CEGIR investigators; Pediatrics, School of Medicine
    Introduction: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations. Methods: Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features. Results: Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002). Discussion: Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies.