Browsing by Subject "Economic evaluation"

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    Correction to: Design of an international multicentre RCT on group schema therapy for borderline personality disorder
    (BMC, 2022-03-25) Wetzelaer, Pim; Farrell, Joan; Evers, Silvia M.A.A.; Jacob, Gitta A.; Lee, Christopher W.; Brand, Odette; van Breukelen, Gerard; Fassbinder, Eva; Fretwell, Heather; Harper, R. Patrick; Lavender, Anna; Lockwood, George; Malogiannis, Ioannis A.; Schweiger, Ulrich; Startup, Helen; Stevenson, Teresa; Zarbock, Gerhard; Arntz, Arnoud; Psychology, School of Science
    Correction to: BMC Psychiatry 14, 319 (2014) https://doi.org/10.1186/s12888-014-0319-3 Following publication of the original article [1], the authors identified errors in the numbers of the below sentences. The updated numbers are given below and the changes have been highlighted in bold typeface. The sentences currently read: In format A (GST-A), two-year GST consists of 124 groups sessions with a duration of 90 minutes. In addition, in GST-A a total of up to 18 individual sessions can be used at the patients discretion or in times of crisis. In total, patients in this condition receive 74 group sessions and 62 individual sessions. The sentences should read: In format A (GST-A), two-year GST consists of 118 groups sessions with a duration of 90 minutes. In addition, in GST-A a total of up to 17 individual sessions can be used at the patients discretion or in times of crisis. In total, patients in this condition receive 63 group sessions and 61 individual sessions. The original article [1] has been corrected.
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    Economic evaluation of postdischarge malaria chemoprevention in preschool children treated for severe anaemia in Malawi, Kenya, and Uganda: A cost-effectiveness analysis
    (Elsevier, 2022-10-01) Kühl, Melf-Jakob; Gondwe, Thandile; Dhabangi, Aggrey; Kwambai, Titus K.; Mori, Amani T.; Opoka, Robert; John, C. Chandy; Idro, Richard; ter Kuile, Feiko O.; Phiri, Kamija S.; Robberstad, Bjarne; Pediatrics, School of Medicine
    Background: Children hospitalised with severe anaemia in malaria-endemic areas are at a high risk of dying or being readmitted within six months of discharge. A trial in Kenya and Uganda showed that three months of postdischarge malaria chemoprevention (PDMC) with monthly dihydroartemisinin-piperaquine (DP) substantially reduced this risk. The World Health Organization recently included PDMC in its malaria chemoprevention guidelines. We conducted a cost-effectiveness analysis of community-based PDMC delivery (supplying all three PDMC-DP courses to caregivers at discharge to administer at home), facility-based PDMC delivery (monthly dispensing of PDMC-DP at the hospital), and the standard of care (no PDMC). Methods: We combined data from two recently completed trials; one placebo-controlled trial in Kenya and Uganda collecting efficacy data (May 6, 2016 until November 15, 2018; n=1049), and one delivery mechanism trial from Malawi collecting adherence data (March 24, 2016 until October 3, 2018; n=375). Cost data were collected alongside both trials. Three Markov decision models, one each for Malawi, Kenya, and Uganda, were used to compute incremental cost-effectiveness ratios expressed as costs per quality-adjusted life-year (QALY) gained. Deterministic and probabilistic sensitivity analyses were performed to account for uncertainty. Findings: Both PDMC strategies were cost-saving in each country, meaning less costly and more effective in increasing health-adjusted life expectancy than the standard of care. The estimated incremental cost savings for community-based PDMC compared to the standard of care were US$ 22·10 (Malawi), 38·52 (Kenya), and 26·23 (Uganda) per child treated. The incremental effectiveness gain using either PDMC strategy varied between 0·3 and 0·4 QALYs. Community-based PDMC was less costly and more effective than facility-based PDMC. These results remained robust in sensitivity analyses. Interpretation: PDMC under implementation conditions is cost-saving. Caregivers receiving PDMC at discharge is a cost-effective delivery strategy for implementation in malaria-endemic southeastern African settings.
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    Health literacy and cumulative social disadvantage are associated with survival and transplant in patients with hepatocellular carcinoma: a prospective study
    (BMJ, 2024-10-02) Nephew, Lauren D.; Rawl, Susan M.; Carter, Allie; Garcia, Nicole; Monahan, Patrick O.; Holden, John; Ghabril, Marwan; Montalvan-Sanchez, Eleazar; Patidar, Kavish; Desai, Archita P.; Orman, Eric; Chalasani, Naga; Medicine, School of Medicine
    Objective: To investigate how individual social determinants of health (SDOH) and cumulative social disadvantage (CSD) affect survival and receipt of liver transplant (LT) in patients with hepatocellular carcinoma (HCC). Methods: We enrolled 139 adult patients from two Indianapolis hospital systems between June 2019 and April 2022. Structured questionnaires collected SDOH and social risk factor data. We compared SDOH and CSD by race, gender and disease aetiology, assigning one point per adverse SDOH. Multivariable competing risk survival analysis assessed associations between SDOH, CSD, survival and LT receipt. Results: Black patients experienced higher CSD than white patients in the cohort (5.4±2.5 vs 3.2±2.1, p<0.001). Black patients were significantly more likely to have household incomes