Browsing by Subject "Dipeptidylpeptidase IV"

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    Concise Review: A Role for DEK in Stem/Progenitor Cell Biology
    (Oxford University Press, 2013) Broxmeyer, Hal E.; Mor-Vaknin, Nirit; Kappes, Ferdinand; Legendre, Maureen; Saha, Anjan K.; Ou, Xuan; O’Leary, Heather; Capitano, Maegan; Cooper, Scott; Markovitz, David M.; Microbiology and Immunology, School of Medicine
    Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulate hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of long-term marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long-term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.