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Item Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis(Annual Reviews, 2020) Rayz, Vitaliy L.; Cohen-Gadol, Aaron A.; Neurological Surgery, School of MedicineIn the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal disease progression or treatment outcomes. Nevertheless, intra-aneurysmal flow analysis has not been adopted in current clinical practice, and hemodynamic factors usually are not considered in clinical decision making. This review presents the state of the art in cerebral aneurysm imaging and image-based modeling, discussing the advantages and limitations of each approach and focusing on the translational value of hemodynamic analysis. Combining imaging and modeling data obtained from different flow modalities can improve the accuracy and fidelity of resulting velocity fields and flow-derived factors that are thought to affect aneurysmal disease progression. It is expected that predictive models utilizing hemodynamic factors in combination with patient medical history and morphological data will outperform current risk scores and treatment guidelines. Possible future directions include novel approaches enabling data assimilation and multimodality analysis of cerebral aneurysm hemodynamics.Item Multi-sensor remote sensing for drought characterization: current status, opportunities and a roadmap for the future(Elsevier, 2021-04) Jiao, Wenzhe; Wang, Lixin; McCabe, Matthew F.; Earth Sciences, School of ScienceSatellite based remote sensing offers one of the few approaches able to monitor the spatial and temporal development of regional to continental scale droughts. A unique element of remote sensing platforms is their multi-sensor capability, which enhances the capacity for characterizing drought from a variety of perspectives. Such aspects include monitoring drought influences on vegetation and hydrological responses, as well as assessing sectoral impacts (e.g., agriculture). With advances in remote sensing systems along with an increasing range of platforms available for analysis, this contribution provides a timely and systematic review of multi-sensor remote sensing drought studies, with a particular focus on drought related datasets, drought related phenomena and mechanisms, and drought modeling. To explore this topic, we first present a comprehensive summary of large-scale remote sensing datasets that can be used for multi-sensor drought studies. We then review the role of multi-sensor remote sensing for exploring key drought related phenomena and mechanisms, including vegetation responses to drought, land-atmospheric feedbacks during drought, drought-induced tree mortality, drought-related ecosystem fires, post-drought recovery and legacy effects, flash drought, as well as drought trends under climate change. A summary of recent modeling advances towards developing integrated multi-sensor remote sensing drought indices is also provided. We conclude that leveraging multi-sensor remote sensing provides unique benefits for regional to global drought studies, particularly in: 1) revealing the complex drought impact mechanisms on ecosystem components; 2) providing continuous long-term drought related information at large scales; 3) presenting real-time drought information with high spatiotemporal resolution; 4) providing multiple lines of evidence of drought monitoring to improve modeling and prediction robustness; and 5) improving the accuracy of drought monitoring and assessment efforts. We specifically highlight that more mechanism-oriented drought studies that leverage a combination of sensors and techniques (e.g., optical, microwave, hyperspectral, LiDAR, and constellations) across a range of spatiotemporal scales are needed in order to progress and advance our understanding, characterization and description of drought in the future.Item Patient-GAT: Sarcopenia Prediction using Multi-modal Data Fusion and Weighted Graph Attention Networks(Association for Computing Machinery, 2023) Xiao, Cary; Imel, Erik A.; Pham, Nam; Luo, Xiao; Medicine, School of MedicineGraph Attention Networks (GAT) have been extensively used to perform node-level classification on data that can be represented as a graph. However, few papers have investigated the effectiveness of using GAT on graph representations of patient similarity networks. This paper proposes Patient-GAT, a novel method to predict chronic health conditions by first integrating multi-modal data fusion to generate patient vector representations using imputed lab variables with other structured data. This data representation is then used to construct a patient network by measuring patient similarity, finally applying GAT to the patient network for disease prediction. We demonstrated our framework by predicting sarcopenia using real-world EHRs obtained from the Indiana Network for Patient Care. We evaluated the performance of our system by comparing it to other baseline models, showing that our model outperforms other methods. In addition, we studied the contribution of the temporal representation of the lab data and discussed the interpretability of this model by analyzing the attention coefficients of the trained Patient-GAT model. Our code can be found on Github.