Browsing by Subject "Cues"

Now showing 1 - 4 of 4
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    Negative urgency and ventromedial prefrontal cortex responses to alcohol cues: FMRI evidence of emotion-based impulsivity
    (Wiley Blackwell (Blackwell Publishing), 2014-02) Cyders, Melissa A.; Dzemidzic, Mario; Eiler, William J.; Coskunpinar, Ayca; Karyadi, Kenny; Kareken, David A.; Department of Psychology, IU School of Science
    BACKGROUND: Recent research has highlighted the role of emotion-based impulsivity (negative and positive urgency personality traits) for alcohol use and abuse, but has yet to examine how these personality traits interact with the brain's motivational systems. Using functional magnetic resonance imaging (fMRI), we tested whether urgency traits and mood induction affected medial prefrontal responses to alcohol odors (AcO). METHODS: Twenty-seven social drinkers (mean age = 25.2, 14 males) had 6 fMRI scans while viewing negative, neutral, or positive mood images (3 mood conditions) during intermittent exposure to AcO and appetitive control (AppCo) aromas. RESULTS: Voxel-wise analyses (p < 0.001) confirmed [AcO > AppCo] activation throughout medial prefrontal cortex (mPFC) and ventromedial PFC (vmPFC) regions. Extracted from a priori mPFC and vmPFC regions and analyzed in Odor (AcO, AppCo) × Mood factorial models, AcO activation was greater than AppCo in left vmPFC (p < 0.001), left mPFC (p = 0.002), and right vmPFC (p = 0.01) regions. Mood did not interact significantly with activation, but the covariate of trait negative urgency accounted for significant variance in left vmPFC (p = 0.01) and right vmPFC (p = 0.01) [AcO > AppCo] activation. Negative urgency also mediated the relationship between vmPFC activation and both (i) subjective craving and (ii) problematic drinking. CONCLUSIONS: The trait of negative urgency is associated with neural responses to alcohol cues in the vmPFC, a region involved in reward value and emotion-guided decision-making. This suggests that negative urgency might alter subjective craving and brain regions involved in coding reward value.
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    Oral Conditioned Cues Can Enhance or Inhibit Ethanol (EtOH)-Seeking and EtOH-Relapse Drinking by Alcohol-Preferring (P) Rats
    (Wiley Blackwell (Blackwell Publishing), 2016-04) Knight, Christopher P.; Hauser, Sheketha R.; Deehan, Gerald A.; Toalston, Jamie E.; McBride, William J.; Rodd, Zachary A.; Psychiatry, School of Medicine
    BACKGROUND: Conditioned cues can elicit drug-seeking in both humans and rodents. The majority of preclinical research has employed excitatory conditioned cues (stimuli present throughout the availability of a reinforcer), but oral consumption of alcohol is similar to a conditional stimuli (presence of stimuli is paired with the delivery of the reinforcer) approach. The current experiments attempted to determine the effects of conditional stimuli (both excitatory and inhibitory) on the expression of context-induced ethanol (EtOH)-seeking. METHODS: Alcohol-preferring (P) rats self-administered EtOH and water in standard 2-lever operant chambers. A flavor was added to the EtOH solution (CS+) during the EtOH self-administration sessions. After 10 weeks, rats underwent extinction training (7 sessions), followed by a 2-week home cage period. Another flavor was present during extinction (CS-). Rats were exposed to a third flavor in a non-drug-paired environment (CS(0)). EtOH-seeking was assessed in the presence of no cue, CS+, CS-, or CS(0) in the dipper previously associated with EtOH self-administration (no EtOH available). Rats were maintained a week in their home cage before being returned to the operant chambers with access to EtOH (flavored with no cue, CS+, CS-, or CS(0)). RESULTS: The results indicated that the presence of the CS+ enhanced EtOH-seeking, while the presence of the CS- suppressed EtOH-seeking. Similarly, adding the CS- flavor to 15% EtOH reduced responding for EtOH while the CS+ enhanced responding for EtOH during relapse testing. CONCLUSIONS: Overall, the data indicate that conditional stimuli are effective at altering both EtOH-seeking behavior and EtOH-relapse drinking.
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    Tolcapone suppresses ethanol intake in alcohol-preferring rats performing a novel cued access protocol
    (Wiley Blackwell (Blackwell Publishing), 2014-09) McCane, Aqilah M.; Czachowski, Cristine L.; Lapish, Christopher C.; Department of Psychology, IU School of Science
    BACKGROUND: Dopamine (DA) has been shown to play a central role in regulating motivated behavior and encoding reward. Chronic drug abuse elicits a state of hypodopaminergia in the mesocorticolimbic (MCL) system in both humans and preclinical rodent models of addiction, including those modeling alcohol use disorders (AUD). METHODS: Working under the hypothesis that reductions in the bioavailability of DA play an integral role in the expression of the excessive drinking phenotype, the catechol-O-methyltransferase (COMT) inhibitor tolcapone was used as a means to amplify cortical DA concentration and drinking behaviors were then assessed. Sucrose and ethanol (EtOH) consumption were measured in P and Wistar rats in both a free choice drinking protocol and a novel cued access protocol. RESULTS: Tolcapone attenuated the consumption of EtOH, and to a lesser extent sucrose, in P rats in the cued access protocol, while no effect was observed in the free choice drinking protocol. Tolcapone also decreased EtOH consumption in high drinking Wistar rats. A follow-up experiment using the indirect DA agonist d-amphetamine showed no change in EtOH consumption. CONCLUSIONS: Collectively, these data suggest that COMT inhibitors may be capable of alleviating the extremely motivating or salient nature of stimuli associated with alcohol. The hypothesis is put forth that the relative specificity of tolcapone for cortical DA systems may mediate the suppression of the high seeking/drinking phenotype.
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    Understanding the Role of Cues in Predicting Physical Activity Behavior
    (2023-06) Jochim, Alexander; Kaushal, Navin; Munk, Niki; Wierenga, Kelly
    Cues have been theorized to promote health behaviors but currently our understanding of the effectiveness of cues is inconclusive. The purpose of this systematic review was to assess the effectiveness of cue interventions in promoting physical activity (PA). Six databases were searched which captured 3,996 articles. After comparison with the eligibility criteria, 19 articles were included in the review. Data extraction revealed that while cues were effective in increasing PA behavior, less than half of the studies (n = 8) were supported by theory-based methodologies. We concluded that cue-based interventions are effective for promoting PA behavior, but future research must develop valid measures of cues and incorporate theory into their study designs. The purpose of the thesis study aimed to address this gap by testing if cue consistency would help explain PA habit and behavior through the Dual Process approach. We conducted an observational study with two measurement periods. We recruited 196 participants via an online volunteer registry. Participants completed measures of exercise behavior, intention, habit, perceived behavioral control (PBC), affective attitudes, and cue consistency at baseline and one month later. We ran a Hierarchical Multiple Regression analysis to determine whether a) habit, intention, PBC, affective attitudes, and cue consistency predicted moderate-vigorous physical activity (MVPA) and b) whether PBC, affective attitudes, and cue consistency predicted habit. Our results showed that MVPA was significantly predicted by habit (β = 0.23, p < 0.01), intention (β = 0.16, p < 0.05), PBC (β = 0.23, p < 0.01), affective attitudes (β = 0.20, p < 0.05), and cue consistency (β = -0.20, p < 0.05). Habit was predicted by affective attitudes (β = 0.48, p < 0.001) and cue consistency (β = 0.32, p < 0.001), but PBC (β = 0.10, p = 0.11) was not significant. We found a stronger relationship between cue consistency and habit than previous studies that evaluated cues individually, supporting the cue consistency construct. Our results suggest that cue consistency should be incorporated in the Dual Process approach as a determinant of habit. Future research should look to replicate our findings through cue-based interventions grounded in theory.