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Browsing by Subject "Complexity"
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Item "Every Interaction is an Intervention": A Case Study Employing a Communication Complex Approach to Addressing Community Mental Health in a Low-Middle Income Country(2024-03) Goodin, Lisann Renee; Parrish-Sprowl, John; Longtin, Krista; Goering, Beth; Schwebach, GaryHistorically, community engagement projects have been addressed from traditional approaches of looking at physical, mental, and social health separately instead of seeing how they are intertwined elements in making up a person’s whole health. Implying the systemic connection between all health and not just the absence of disease engages the World Health Organization’s definition of health. There is a need to shift to a complex approach known as communication complex that better supports complex environments like Low-Middle Income Countries. Communication complex is a meta-perspective that helps design a quantum complexity framework that engages the bioactive nature of communication and the systemic interconnection of everything. When communication complex is applied to the context of health, this is known as Communication for Whole Health which is an interventional framework. This approach informed the development of the following research questions: RQ1: How might researchers meld into a community to promote CWH? RQ2: How can the shifting trajectory from a culture of reactivity to one of receptivity be assessed? The methodological approach for this study is looking at a case study as an ethnographic participant observer within participatory action research to observe and understand where interventions have occurred within the community. This study found that researchers can meld into a community through a relational multi-interventional process by focusing on building healthy relationships with Communication for Whole Health practices. Further findings discovered that to assess how a culture shifts from a culture of reactivity to receptivity, this occurs through an evaluative approach that is not traditional of being done to an organization but rather observing how relationships change in conversation. In conclusion, using a Communication for Whole Health approach for community engagement that moves from object to relational provides a better framework to respond to a complex environment with minimal resources.Item Evidence for a Strong Correlation Between Transcription Factor Protein Disorder and Organismic Complexity(Oxford University Press, 2017-05-01) Yruela, Inmaculada; Oldfield, Christopher J.; Niklas, Karl J.; Dunker, A. Keith; Department of Biochemistry and Molecular Biology, School of MedicineStudies of diverse phylogenetic lineages reveal that protein disorder increases in concert with organismic complexity but that differences nevertheless exist among lineages. To gain insight into this phenomenology, we analyzed all of the transcription factor (TF) families for which sequences are known for 17 species spanning bacteria, yeast, algae, land plants, and animals and for which the number of different cell types has been reported in the primary literature. Although the fraction of disordered residues in TF sequences is often moderately or poorly correlated with organismic complexity as gauged by cell-type number (r2 < 0.5), an unbiased and phylogenetically broad analysis shows that organismic complexity is positively and strongly correlated with the total number of TFs, the number of their spliced variants and their total disordered residues content (r2 > 0.8). Furthermore, the correlation between the fraction of disordered residues and cell-type number becomes stronger when confined to the TF families participating in cell cycle, cell size, cell division, cell differentiation, or cell proliferation, and other important developmental processes. The data also indicate that evolutionarily simpler organisms allow for the detection of subtle differences in the conserved IDRs of TFs as well as changes in variable IDRs, which can influence the DNA recognition and multifunctionality of TFs through direct or indirect mechanisms. Although strong correlations cannot be taken as evidence for cause-and-effect relationships, we interpret our data to indicate that increasing TF disorder likely was an important factor contributing to the evolution of organismic complexity and not merely a concurrent unrelated effect of increasing organismic complexity.Item Selecting a change and evaluating its impact on the performance of a complex adaptive health care delivery system(Dove Medical Press, 2010-05-05) Boustani, Malaz A.; Munger, Stephanie; Gulati, Rajesh; Vogel, Mickey; Beck, Robin A.; Callahan, Christopher M.; Medicine, School of MedicineComplexity science suggests that our current health care delivery system acts as a complex adaptive system (CAS). Such systems represent a dynamic and flexible network of individuals who can coevolve with their ever changing environment. The CAS performance fluctuates and its members’ interactions continuously change over time in response to the stress generated by its surrounding environment. This paper will review the challenges of intervening and introducing a planned change into a complex adaptive health care delivery system. We explore the role of the “reflective adaptive process” in developing delivery interventions and suggest different evaluation methodologies to study the impact of such interventions on the performance of the entire system. We finally describe the implementation of a new program, the Aging Brain Care Medical Home as a case study of our proposed evaluation process.