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Item Automated Evaluation of Neurological Disorders Through Electronic Health Record Analysis(2024-08) Prince, Md Rakibul Islam; Ben Miled, Zina; El-Sharkawy, Mohamed A.; Zhang, QingxueNeurological disorders present a considerable challenge due to their variety and diagnostic complexity especially for older adults. Early prediction of the onset and ongoing assessment of the severity of these disease conditions can allow timely interventions. Currently, most of the assessment tools are time-consuming, costly, and not suitable for use in primary care. To reduce this burden, the present thesis introduces passive digital markers for different disease conditions that can effectively automate the severity assessment and risk prediction from different modalities of electronic health records (EHR). The focus of the first phase of the present study in on developing passive digital markers for the functional assessment of patients suffering from Bipolar disorder and Schizophrenia. The second phase of the study explores different architectures for passive digital markers that can predict patients at risk for dementia. The functional severity PDM uses only a single EHR modality, namely medical notes in order to assess the severity of the functioning of schizophrenia, bipolar type I, or mixed bipolar patients. In this case, the input of is a single medical note from the electronic medical record of the patient. This note is submitted to a hierarchical BERT model which classifies at-risk patients. A hierarchical attention mechanism is adopted because medical notes can exceed the maximum allowed number of tokens by most language models including BERT. The functional severity PDM follows three steps. First, a sentence-level embedding is produced for each sentence in the note using a token-level attention mechanism. Second, an embedding for the entire note is constructed using a sentence-level attention mechanism. Third, the final embedding is classified using a feed-forward neural network which estimates the impairment level of the patient. When used prior to the onset of the disease, this PDM is able to differentiate between severe and moderate functioning levels with an AUC of 76%. Disease-specific severity assessment PDMs are only applicable after the onset of the disease and have AUCs of nearly 85% for schizophrenia and bipolar patients. The dementia risk prediction PDM considers multiple EHR modalities including socio-demographic data, diagnosis codes and medical notes. Moreover, the observation period and prediction horizon are varied for a better understanding of the practical limitations of the model. This PDM is able to identify patients at risk of dementia with AUCs ranging from 70% to 92% as the observation period approaches the index date. The present study introduces methodologies for the automation of important clinical outcomes such as the assessment of the general functioning of psychiatric patients and the prediction of risk for dementia using only routine care data.Item Community Recommendation in Social Networks with Sparse Data(2020-12) Rahmaniazad, Emad; King, Brian; Jafari, Ali; Salama, PaulRecommender systems are widely used in many domains. In this work, the importance of a recommender system in an online learning platform is discussed. After explaining the concept of adding an intelligent agent to online education systems, some features of the Course Networking (CN) website are demonstrated. Finally, the relation between CN, the intelligent agent (Rumi), and the recommender system is presented. Along with the argument of three different approaches for building a community recommendation system. The result shows that the Neighboring Collaborative Filtering (NCF) outperforms both the transfer learning method and the Continuous bag-of-words approach. The NCF algorithm has a general format with two various implementations that can be used for other recommendations, such as course, skill, major, and book recommendations.Item A Study of Transformer Models for Emotion Classification in Informal Text(2021-12) Esperanca, Alvaro Soares de Boa; King, Brian; Luo, Xiao; Ding, ZhenmingTextual emotion classification is a task in affective AI that branches from sentiment analysis and focuses on identifying emotions expressed in a given text excerpt. It has a wide variety of applications that improve human-computer interactions, particularly to empower computers to understand subjective human language better. Significant research has been done on this task, but very little of that research leverages one of the most emotion-bearing symbols we have used in modern communication: Emojis. In this thesis, we propose several transformer-based models for emotion classification that processes emojis as input tokens and leverages pretrained models and uses them , a model that processes Emojis as textual inputs and leverages DeepMoji to generate affective feature vectors used as reference when aggregating different modalities of text encoding. To evaluate ReferEmo, we experimented on the SemEval 2018 and GoEmotions datasets, two benchmark datasets for emotion classification, and achieved competitive performance compared to state-of-the-art models tested on these datasets. Notably, our model performs better on the underrepresented classes of each dataset.