Browsing by Subject "BCS"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Endpoints for Mouse Abdominal Tumor Models: Refinement of Current Criteria
    (American Association for Laboratory Animal Science, 2009-06) Paster, Eden V.; Villines, Kimberly A.; Hickman, Debra L.; Laboratory Animal Resource Center, IU School of Medicine
    Accurate, rapid, and noninvasive health assessments are required to establish more appropriate endpoints in mouse cancer models where tumor size is not easily measured. We evaluated potential endpoints in mice with experimentally induced peritoneal lymphoma, an abdominal tumor model, by comparing body weight, body condition, and behavior with those of a control group of mice not developing lymphoma. Our hypothesis was that body weight would increase or plateau, whereas body condition and behavioral scores would decrease, as disease progressed. Results indicated that body weight did not differ significantly between the control and experimental groups, but the experimental group experienced significant decreases in both body condition and behavioral scores. Our results support the use of body condition and behavioral scoring as adjunctive assessment methods for mice involved in abdominal lymphoma tumor studies in which health may decline despite an increase or plateau in body weight.
  • Thumbnail Image
    Item
    Use of a body condition score technique to assess health status in a rat model of polycystic kidney disease
    (American Association for Laboratory Animal Science, 2010-03) Hickman, Debra L.; Swan, Melissa; Laboratory Animal Resource Center, IU School of Medicine
    Simple and noninvasive methods of assessing health and wellbeing are valuable when performing clinical evaluation of rodents used in biomedical research. Body condition score (BCS) techniques have been described for a variety of species, including mice. This method can be a sensitive objective assessment of weight loss in animal models where organ enlargement, ascites, or tumor development may mask weight loss. Although deposition of fat is similar in rats and mice, the mouse BCS technique has not been characterized in rats. Here we used the Han:SPRD rat model for polycystic kidney disease to characterize the effectiveness of the mouse BCS scale when applied to rats. This study showed a positive correlation between BCS score and renal function and a negative correlation between weight and renal function, supporting the use of BCS as an effective, noninvasive method of health assessment in this rat model. Our results also demonstrate that the BCS scale described for mice required a slight modification to capture the delay in fat deposition over the lumbar vertebrae in obese animals.