Browsing by Subject "Anatomy"
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Item Accuracy of MRI in Assessment of High-Grade Partial Distal Biceps Tears(Sage, 2025) Schmidt, Gregory J.; Fischer, James P.; Hoyer, Reed W.; Greenberg, Jeffrey A.; Crosby, Nicholas E.; Graduate Medical Education, School of MedicineBackground: Magnetic resonance imaging (MRI) is commonly used to diagnose and assess the extent of partial distal biceps injuries. The aim of this study was to report on the accuracy of MRI and the effect of injury history and study timing on its performance. Methods: A retrospective review of all patients who underwent surgical treatment of partial thickness distal biceps tears at a single center by multiple surgeons was performed. Inclusion criteria consisted of the performance of a preoperative MRI and documentation of the intraoperatively visualized extent of the tear, and 68 patients met the criteria for inclusion. A chart review was completed to evaluate the symptom duration, injury history, and tear extent. Results: All patients had distal biceps tears of greater than 50% intraoperatively. However, MRI did not indicate any tearing in 20 (29%) patients, and its sensitivity for high-grade tear was 44%. Magnetic resonance imaging was significantly less likely to be read as high-grade tears in patients with insidious onset of their symptoms in comparison with patients who reported a traumatic onset (27% vs 55%, P = .024). However, the time from symptom onset to MRI did not significantly correlate with diagnosis of a high-grade tear on MRI (r = -0.15, P = .21). Conclusions: These results indicate that MRI can underreport partial distal biceps tear extent, and this more commonly occurs in patients with insidious onset of pain.Item Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy(PLOS, 2022-06-09) Sanders, Katherine A.; Philp, Janet A.C.; Jordan, Crispin Y.; Cale, Andrew S.; Cunningham, Claire L.; Organ, Jason M.; Anatomy, Cell Biology and Physiology, School of MedicineAnatomy Nights is an international public engagement event created to bring anatomy and anatomists back to public spaces with the goal of increasing the public's understanding of their own anatomy by comparison with non-human tissues. The event consists of a 30-minute mini-lecture on the anatomy of a specific anatomical organ followed by a dissection of animal tissues to demonstrate the same organ anatomy. Before and after the lecture and dissection, participants complete research surveys designed to assess prior knowledge and knowledge gained as a result of participation in the event, respectively. This study reports the results of Anatomy Nights brain events held at four different venues in the UK and USA in 2018 and 2019. Two general questions were asked of the data: 1) Do participant post-event test scores differ from pre-event scores; and 2) Are there differences in participant scores based on location, educational background, and career. We addressed these questions using a combination of generalized linear models (R's glm function; R version 4.1.0 [R Core Team, 2014]) that assumed a binomial distribution and implemented a logit link function, as well as likelihood estimates to compare models. Survey data from 91 participants indicate that scores improve on post-event tests compared to pre-event tests, and these results hold irrespective of location, educational background, and career. In the pre-event tests, participants performed well on naming structures with an English name (frontal lobe and brainstem), and showed signs of improvement on other anatomical names in the post-test. Despite this improvement in knowledge, we found no evidence that participation in Anatomy Nights improved participants' ability to apply this knowledge to neuroanatomical contexts (e.g., stroke).Item Build-A-Pelvis: a Low-cost Modeling Activity to Improve Medical Students’ Understanding of Perineal Anatomy(Springer, 2019-07-26) Smith, Theodore C.; Husmann, Polly; Medicine, School of MedicineBackground: We demonstrate a low-cost, active learning module that provides medical students with a three-dimensional understanding of perineal anatomy. Activity: Student groups completed a perineal model and then reviewed another group's model of the opposite sex. Multiple pre- and post-module quizzes and correlated exam questions were analyzed. Self-reported understanding of perineal anatomy and usefulness of activity were reported. Results: Students showed significant increases between pre- and post-quiz scores and perceptions of understanding (p < 0.001). Outcomes on exam questions were significantly higher than non-participating counterparts (p = 0.011). Discussion: Thus, this low-cost modeling activity can benefit learning of perineal anatomy.Item CHAPTER 12 - Non-neoplastic diseases of the testis(Elsevier, 2020-06-22) Nistal, Manuel; Paniagua, Ricardo; Bostwick, David G.; Cheng, Liang; Pathology and Laboratory Medicine, School of MedicineItem Congenital anatomic variations in a pancreas allograft: Is this consistent with safe transplant?(Elsevier, 2022) Walia, Sonal; Powelson, John A.; Lutz, Andrew J.; Fridell, Jonathan A.; Surgery, School of MedicineItem Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris(Springer Nature, 2023-12-19) An, Senyou; Yu, Huidan; Islam, MD Mahfuzul; Zhang, Xiaoyu; Zhan, Yuting; Olivieri, Joseph J.; Ambati, Jayakrishna; Yao, Jun; Gelfand, Bradley D.; Mechanical and Energy Engineering, Purdue School of Engineering and TechnologyEvidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. Therefore, we sought to understand the influences of choroidal microvascular architecture on the spatial distribution of hemodynamic parameters in choriocapillaris from human donor eyes using image-based computational hemodynamic (ICH) simulations. We subjected image-based inner choroid reconstructions from eight human donor eyes to ICH simulation using a kinetic-based volumetric lattice Boltzmann method to compute hemodynamic distributions of velocity, pressure, and endothelial shear stress. Here, we demonstrate that anatomic parameters, including arteriolar and venular arrangements and intercapillary pillar density and distribution exert profound influences on inner choroidal hemodynamic characteristics. Reductions in capillary, arteriolar, and venular density not only reduce the overall blood velocity within choriocapillaris, but also substantially increase its spatial heterogeneity. These first-ever findings improve understanding of how choroidal anatomy affects hemodynamics and may contribute to pathogenesis of retinal diseases such as AMD.Item Efficacy of Novel Bracing for Treating Sciatica and Cadaveric Dissection to Examine Excursion of the Sciatic Nerve(2023-07-28) Callahan, Kyle; Dellacqua, DaleBackground/Objective: Sciatica affects nearly half of all Americans and can often become debilitating, leading to severe pain that can limit performing activities of daily living. Brace application has not been tried for alleviation of pain. In this study, we seek to find if a novel brace can decrease pain and decrease bothersome level of symptoms for those suffering from sciatica. In addition, this study utilizes a cadaveric dissection to understand how the sciatic nerve stretches and tensions upon lower limb manipulation. Methods: Fourteen patients self-reported pain, functionality, and bothersome levels pre- and post-bracing. Excel’s data analysis tool was utilized to run statistical tests. One cadaver (2 lower limbs) was dissected, revealing the sciatic nerve at the hip and knee, while tibial nerve at the ankle. Excursion was measured utilizing a fixed pin and an initial distance, the leg manipulated, and final distance from pin measured. Ultimately, excursion was deemed final distance minus initial distance from the pin. Results: The brace decreases Visual Analogue Scale (VAS) scores, increases Patient Reported Outcomes, and decreases Sciatica Bothersome Indexes. There was a significant difference in VAS pre- versus post-brace values at initial and 7-day post-visit but not at 21- or 42-day post-visit. Sciatic nerve excursion was greatest at the ankle. Discussion/Conclusion Brace use decreases pain levels, increases functionality, and decreases bothersome level of symptoms. The distal nerve moves more upon manipulation and therefore is more prone to tensioning than the proximal nerve. Dissection data illustrates how the brace positions the limb in a way that promotes “detensioning” of the nerve, alleviating sciatica. More cadaver data is needed. Presentation recording available online: https://purl.dlib.indiana.edu/iudl/media/c58059kh24Item External cortical landmarks and measurements for the temporal horn: Anatomic study with application to surgery of the temporal lobe(Wolters Kluwer, 2015-02-03) Tubbs, R. Shane; Sharma, Amit; Loukas, Marios; Cohen-Gadol, Aaron; Department of Neurological Surgery, IU School of MedicineBACKGROUND: The location of the temporal horn is important to neurosurgeons during procedures such as amygdalohippocampectomy and intraventricular electrode placement for temporal lobe seizure monitoring. However, sometimes the temporal horn is difficult to localize, especially without neuronavigation. The authors aimed to better localize this structure using superficial anatomic landmarks. METHODS: Twenty-two brain halves were dissected from the midline, and the fornix identified and followed toward the left and right temporal horns. Once the temporal horn was isolated from a mesial approach, 6-cm long needles were placed into its anterior and posterior walls of the temporal horn and passed laterally from the axial plane to the cortical surface. Pin exit sites were marked externally and measurements taken between the outer temporal lobe cortex and the underlying temporal horn. RESULTS: No statistical differences were noted between left and right sides. The temporal horn was generally directed anteroinferiorly and best marked externally by the inferior temporal sulcus. The mean length of the temporal horn was 4.4 cm. Mean distance from anterior temporal tip to anterior wall of the temporal horn was 3.3 cm. The mean distance from the anterior temporal tip to the posterior wall of the temporal horn was 7 cm. The anterior wall of the temporal horn was a mean of 3 mm superior to the inferior temporal sulcus. The posterior wall was a mean of 1.2 cm superior to the inferior temporal sulcus. CONCLUSIONS: These landmarks and measurements may help neurosurgeons better localize this part of the lateral ventricular system.Item External cortical landmarks for localization of the hippocampus: Application for temporal lobectomy and amygdalohippocampectomy(Scientific Scholar, 2018-08-22) Tubbs, R. Shane; Loukas, Marios; Barbaro, Nicholas M.; Shah, Kushal J.; Cohen-Gadol, Aaron A.; Neurological Surgery, School of MedicineBackground: Accessing the hippocampus for amygdalohippocampectomy and minimally invasive procedures, such as depth electrode placement, require an accurate knowledge regarding the location of the hippocampus. Methods: The authors removed 10 human cadaveric brains from the cranium and observed the relationships between the lateral temporal neocortex and the underlying hippocampus. They then measured the distance between the hippocampus and superficial landmarks. The authors also validated their study using magnetic resonance imaging (MRI) scans of 10 patients suffering from medial temporal lobe sclerosis where the distance from the hippocampal head to the anterior temporal tip was measured. Results: In general, the length of the hippocampus was along the inferior temporal sulcus and inferior aspect of the middle temporal gyrus. Although the hippocampus tended to be more superiorly located in female specimens and on the left side, this did not reach statistical significance. The length of the hippocampus tended to be shorter in females, but this too failed to reach statistical significance. The mean distance from the anterior temporal tip to the hippocampal head was identical in the cadavers and MRIs of patients with medial temporal lobe sclerosis. Conclusions: Additional landmarks for localizing the underlying hippocampus may be helpful in temporal lobe surgery. Based on this study, there are relatively constant anatomical landmarks between the hippocampus and overlying temporal cortex. Such landmarks may be used in localizing the hippocampus during amygdalohippocampectomy and depth electrode implantation in verifying the accuracy of image-guided methods and as adjuvant methodologies when these latter technologies are not used or are unavailable.Item From pyramids to columns: the structure of the kidney(ASCP, 2012) Wood, Debra M.