Browsing by Subject "Alstrom syndrome"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Cilia and Obesity
    (Cold Spring Harbor Laboratory Press, 2017-07-05) Vaisse, Christian; Reiter, Jeremy F.; Berbari, Nicolas F.; Biology, School of Science
    The ciliopathies Bardet-Biedl syndrome and Alström syndrome cause obesity. How ciliary dysfunction leads to obesity has remained mysterious, partly because of a lack of understanding of the physiological roles of primary cilia in the organs and pathways involved in the regulation of metabolism and energy homeostasis. Historically, the study of rare monogenetic disorders that present with obesity has informed our molecular understanding of the mechanisms involved in nonsyndromic forms of obesity. Here, we present a framework, based on genetic studies in mice and humans, of the molecular and cellular pathways underlying long-term regulation of energy homeostasis. We focus on recent progress linking these pathways to the function of the primary cilia with a particular emphasis on the roles of neuronal primary cilia in the regulation of satiety.