Browsing by Subject "Alcoholic"

Now showing 1 - 3 of 3
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    Alcohol and fat promote steatohepatitis: a critical role for fat-specific protein 27/CIDEC
    (BMJ Journals, 2016-08) Liangpunsakul, Suthat; Gao, Bin; Medicine, School of Medicine
    Alcoholic liver disease (ALD) is a major public health problem worldwide and is the leading cause of end-stage liver disease. While the ultimate control of ALD will require the prevention of alcohol abuse, better understanding of the mechanisms of alcohol-induced liver injury may lead to treatments of fatty liver, alcoholic hepatitis, and prevention or delay of occurrence of cirrhosis. The elucidation and the discovery of several new concepts in ALD pathogenesis have raised our understanding on the complex mechanisms and the potential in developing the new strategies for therapeutic benefits. In this review, we provide the most up-to-date information on the basic molecular mechanisms focusing on the role of fat-specific protein 27/CIDEC in the pathogenesis of ALD.
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    Epidemiology of Alcohol-associated Liver Disease
    (Elsevier, 2021) Han, Sen; Yang, Zhihong; Zhang, Ting; Ma, Jing; Chandler, Kristina; Liangpunsakul, Suthat; Medicine, School of Medicine
    Alcohol-associated liver disease (ALD) is a consequence of excessive alcohol use. It comprises a spectrum of histopathologic changes ranging from simple steatosis, steatohepatitis, and cirrhosis to hepatocellular carcinoma. The public health impact of ALD is growing because of an increase in the prevalence and incidence of ALD in parallel with liver transplant and mortalities. There are multiple factors involved in the pathogenesis and progression of ALD. Reducing alcohol consumption is the cornerstone of ALD management. The efforts to reduce excessive alcohol use at the individual and population levels are urgently needed to prevent adverse outcomes from ALD.
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    Role of hepatic macrophages in alcoholic liver disease
    (BMJ Journals, 2016-08) Ju, Cynthia; Liangpunsakul, Suthat; Medicine, School of Medicine
    Alcohol consumption can lead to the increase in gut permeability and cause the translocation of bacteria-derived lipopolysaccharides from the gut to the liver, which subsequently activates immune responses. In this process, macrophages play a critical role and involve in the pathogenesis of alcoholic liver disease (ALD). To define the mechanism underpinning the function of macrophages, it is important to conduct extensive studies to further explicate the phenotypic diversity of macrophages in the context of ALD., In this review, the role of hepatic macrophages in the pathogenesis of ALD is discussed.