Browsing by Subject "African American health"

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    Medical Racism and Black Health Activism in Indianapolis and Beyond: Learning Modules for Health Professionals
    (2024) Nelson, Elizabeth
    This set of modules, designed for health care professionals, focuses on the history of health disparities in the United States, with a special focus on Indianapolis. Health disparities between different racial and ethnic groups have been documented since the 1800s. Anti-Black racism has played a central role in the making of modern medicine in the US; Dr. Martin Luther King Jr., considered discrimination in medicine to be the most “shocking and inhuman” form of racism. Civil Rights activists and Black health care professionals have led efforts to minimize health disparities, in Indianapolis and beyond, over many decades. But there is more work to be done. As we build toward a more equitable future, we would be wise to inform ourselves of this past.
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    Type 2 Diabetes Genetic Risk Scores Are Associated With Increased Type 2 Diabetes Risk Among African Americans by Cardiometabolic Status
    (Sage, 2018-01-03) Layton, Jill; Li, Xiaochen; Shen, Changyu; de Groot, Mary; Lange, Leslie; Correa, Adolfo; Wessel, Jennifer; Epidemiology, School of Public Health
    The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. In cardiometabolic-stratified models, the BCD and IR GRS were associated with increased type 2 diabetes risk among 5 cardiometabolic strata: 3 clinically healthy strata and 2 clinically unhealthy strata. Genetic risk scores related to BCD and IR were associated with increased risk of type 2 diabetes in African Americans. Notably, the GRSs were significant predictors of type 2 diabetes among individuals in clinically normal ranges of cardiometabolic traits.