Browsing by Subject "Addictive behavior"

Now showing 1 - 5 of 5
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    Adult Hippocampal Neurogenesis in the Pathogenesis of Addiction and Dual Diagnosis Disorders
    (Elsevier, 2013) Chambers, R. Andrew; Psychiatry, School of Medicine
    Background: As knowledge deepens about how new neurons are born, differentiate, and wire into the adult mammalian brain, growing evidence depicts hippocampal neurogenesis as a special form of neuroplasticity that may be impaired across psychiatric disorders. This review provides an integrated-evidence based framework describing a neurogenic basis for addictions and addiction vulnerability in mental illness. Methods: Basic studies conducted over the last decade examining the effects of addictive drugs on adult neurogenesis and the impact of neurogenic activity on addictive behavior were compiled and integrated with relevant neurocomputational and human studies. Results: While suppression of hippocampal neurogenic proliferation appears to be a universal property of addictive drugs, the pathophysiology of addictions involves neuroadaptative processes within frontal-cortical-striatal motivation circuits that the neurogenic hippocampus regulates via direct projections. States of suppressed neurogenic activity may simultaneously underlie psychiatric and cognitive symptoms, but also confer or signify hippocampal dysfunction that heightens addiction vulnerability in mental illness as a basis for dual diagnosis disorders. Conclusions: Research on pharmacological, behavioral and experiential strategies that enhance adaptive regulation of hippocampal neurogenesis holds potential in advancing preventative and integrative treatment strategies for addictions and dual diagnosis disorders.
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    An interlocked oscillator model for high-frequency firing of the midbrain dopaminergic neuron
    (Springer Nature, 2011-07-18) Kuznetsov, Alexey; Ha, Joon; Mathematical Sciences, School of Science
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    Association between indoor tanning frequency during early life and other potentially addictive behaviors among US women
    (Elsevier, 2021) Tsibris, Hillary C.; Nan, Hongmei; Li, Xin; Global Health, School of Public Health
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    Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologie
    (MDPI, 2023-06-13) Escobar, Angélica P.; Bonansco, Christian; Cruz, Gonzalo; Dagnino-Subiabre, Alexies; Fuenzalida, Marco; Negrón, Ignacio; Sotomayor-Zárate, Ramón; Martínez-Pinto, Jonathan; Jorquera, Gonzalo; Anatomy, Cell Biology and Physiology, School of Medicine
    Many diseases and degenerative processes affecting the nervous system and peripheral organs trigger the activation of inflammatory cascades. Inflammation can be triggered by different environmental conditions or risk factors, including drug and food addiction, stress, and aging, among others. Several pieces of evidence show that the modern lifestyle and, more recently, the confinement associated with the COVID-19 pandemic have contributed to increasing the incidence of addictive and neuropsychiatric disorders, plus cardiometabolic diseases. Here, we gather evidence on how some of these risk factors are implicated in activating central and peripheral inflammation contributing to some neuropathologies and behaviors associated with poor health. We discuss the current understanding of the cellular and molecular mechanisms involved in the generation of inflammation and how these processes occur in different cells and tissues to promote ill health and diseases. Concomitantly, we discuss how some pathology-associated and addictive behaviors contribute to worsening these inflammation mechanisms, leading to a vicious cycle that promotes disease progression. Finally, we list some drugs targeting inflammation-related pathways that may have beneficial effects on the pathological processes associated with addictive, mental, and cardiometabolic illnesses.
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    Intersection of Minority Health, Health Disparities, and Social Determinants of Health With Psychopharmacology and Substance Use
    (American Psychological Association, 2021) Lopez-Vergara, Hector I.; Zapolski, Tamika C. B.; Leventhal, Adam M.; Psychology, School of Science
    These articles provide a window into the breadth of issues at the intersection of MHDS with psychopharmacology and substance use. Integrating the fields of psychopharmacology and basic behavioral addictions science with research on MHDS is not only of public health importance, but can help further elucidate our understanding of human behavior in all of its complexity. As demonstrated here, a better understanding of the synergy between societal context(s) and individual-level processes can lead to interventions tailored to specific risk and resilience factors; interventions that are personalized and contextualized have the potential to improve the health of our society. We are very grateful to the authors for their contributions to this special issue. We hope that professionals from various disciplines who read this special issue become inspired to bridge psychopharmacological and social determinants perspectives in their own work, and, in turn, accelerate scientific progress within each field.