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Item Accuracy of Orthodontic Soft Tissue Prediction Software between Different Ethnicities(2019) Stewart, Kelton; Patel, Pranali; Eckert, George; Rigsbee III, OH; Hughes, Jay; Utreja, AchintObjective: The objective of this study was to assess the accuracy of the soft tissue prediction module of Dolphin Imaging Software (DIS) in patients requiring extractions as part of the orthodontic treatment plan and compare its accuracy between different ethnicities. Materials and Methods: Initial and final records of 57 patients from three ethnic groups (African Americans, Caucasians, and Hispanics) who completed orthodontic treatment were included for assessment. The identified cases were managed non-surgically with dental extractions. A predictive profile was generated using DIS and compared to post-treatment lateral photographs. Actual and predictive profile photographs were compared using five designated parameters. The assessment parameters were evaluated using a manual protractor. ANOVA was used to compare differences between actual and predicted parameters between the specified groups and ICC was used to assess correlations between the data. Results: Neither ethnicity nor gender had a significant effect on the difference between predicted and final values. No significant difference was noted between the predicted and final images for the nasolabial angle. Significant differences were observed for the mentolabial fold, upper lip to E-line, and lower lip to E-line between predicted and actual images. Additionally, soft tissue convexity was significantly different (p=0.019). Additionally, a clinically significant difference was found for the mentolabial fold. Conclusion: Ethnicity and gender had no impact on the accuracy of predicted and actual image parameters. Overall, DIS demonstrated acceptable accuracy when simulating soft tissue changes after extraction therapy. Additional research on the accuracy of the software is warranted.Item Blackford County Horizontal Accuracy Report(2006-01-11T16:31:40Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Blackford County, IndianaItem Dearborn County Horizontal Accuracy Report(2006-01-11T04:46:04Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Dearborn County, IndianaItem Decatur County Horizontal Accuracy Report(2006-01-11T04:54:49Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Decatur County, IndianaItem Fayette County Horizontal Accuracy Report(2006-01-11T04:51:31Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Fayette County, IndianaItem Franklin County Horizontal Accuracy Report(2006-01-11T04:50:52Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Franklin County, IndianaItem Jennings County Horizontal Accuracy Report(2006-01-11T04:52:11Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Jennings County, IndianaItem Ohio County Horizontal Accuracy Report(2006-01-11T04:48:31Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Ohio County, IndianaItem Precision and accuracy of hyperglycemic clamps in a multicenter study(American Physiological Society, 2021) Mather, Kieren J.; Tjaden, Ashley H.; Hoehn, Adam; Nadeau, Kristen J.; Buchanan, Thomas A.; Kahn, Steven E.; Arslanian, Silva A.; Caprio, Sonia; Atkinson, Karen M.; Cree-Green, Melanie; Utzschneider, Kristina M.; Edelstein, Sharon L.; RISE Consortium; Medicine, School of MedicineApplication of glucose clamp methodologies in multicenter studies brings challenges for standardization. The Restoring Insulin Secretion (RISE) Consortium implemented a hyperglycemic clamp protocol across seven centers using a combination of technical and management approaches to achieve standardization. Two-stage hyperglycemic clamps with glucose targets of 200 mg/dL and >450 mg/dL were performed utilizing a centralized spreadsheet-based algorithm that guided dextrose infusion rates using bedside plasma glucose measurements. Clamp operators received initial and repeated training with ongoing feedback based on surveillance of clamp performance. The precision and accuracy of the achieved stage-specific glucose targets were evaluated, including differences by study center. We also evaluated robustness of the method to baseline physiologic differences and on-study treatment effects. The RISE approach produced high overall precision (3%–9% variance in achieved plasma glucose from target at various times across the procedure) and accuracy (SD < 10% overall). Statistically significant but numerically small differences in achieved target glucose concentrations were observed across study centers, within the magnitude of the observed technical variability. Variation of the achieved target glucose over time in placebo-treated individuals was low (<3% variation), and the method was robust to differences in baseline physiology (youth vs. adult, IGT vs. diabetes status) and differences in physiology induced by study treatments. The RISE approach to standardization of the hyperglycemic clamp methodology across multiple study centers produced technically excellent standardization of achieved glucose concentrations. This approach provides a reliable method for implementing glucose clamp methodology across multiple study centers. NEW & NOTEWORTHY: The Restoring Insulin Secretion (RISE) study centers undertook hyperglycemic clamps using a simplified methodology and a decision guidance algorithm implemented in an easy-to-use spreadsheet. This approach, combined with active management including ongoing central data surveillance and routine feedback to study centers, produced technically excellent standardization of achieved glucose concentrations on repeat studies within and across study centers.Item Ripley County Horizontal Accuracy Report(2006-01-11T04:47:00Z)Report and table verifying the accuracy of the 2005 digital aerial photography (orthophotography) for Ripley County, Indiana