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Item Refers to: Paul Enck. Not more, but less studies are warranted—If you take your meta-analysis seriously(Wiley, 2019-01) Shin, Andrea S.; Imperiale, Thomas F.; Medicine, School of MedicineThis submission is in reply to a letter by Dr. Paul Enck regarding our recent conclusions regarding the clinical efficacy of patented probiotic, VSL#3, in Irritable Bowel Syndrome.