Browsing by Author "de Jesus Perez, Vinicio A."

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    Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension
    (American Physiological Society, 2018-03-01) Frump, Andrea L.; Bonnet, Sébastien; de Jesus Perez, Vinicio A.; Lahm, Tim; Medicine, School of Medicine
    Right ventricular (RV) function is the primary prognostic factor for both morbidity and mortality in pulmonary hypertension (PH). RV hypertrophy is initially an adaptive physiological response to increased overload; however, with persistent and/or progressive afterload increase, this response frequently transitions to more pathological maladaptive remodeling. The mechanisms and disease processes underlying this transition are mostly unknown. Angiogenesis has recently emerged as a major modifier of RV adaptation in the setting of pressure overload. A novel paradigm has emerged that suggests that angiogenesis and angiogenic signaling are required for RV adaptation to afterload increases and that impaired and/or insufficient angiogenesis is a major driver of RV decompensation. Here, we summarize our current understanding of the concepts of maladaptive and adaptive RV remodeling, discuss the current literature on angiogenesis in the adapted and failing RV, and identify potential therapeutic approaches targeting angiogenesis in RV failure.
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    Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)
    (Wiley, 2025-01-02) Forbes, Lindsay M.; Bauer, Natalie; Bhadra, Aritra; Bogaard, Harm J.; Choudhary, Gaurav; Goss, Kara N.; Gräf, Stefan; Heresi, Gustavo A.; Hopper, Rachel K.; Jose, Arun; Kim, Yunhye; Klouda, Timothy; Lahm, Tim; Lawrie, Allan; Leary, Peter J.; Leopold, Jane A.; Oliveira, Suellen D.; Prisco, Sasha Z.; Rafikov, Ruslan; Rhodes, Christopher J.; Stewart, Duncan J.; Vanderpool, Rebecca R.; Yuan, Ke; Zimmer, Alexsandra; Hemnes, Anna R.; de Jesus Perez, Vinicio A.; Wilkins, Martin R.; Medicine, School of Medicine
    Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.