Browsing by Author "Zinchuk, Andrey"

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    The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study
    (American Academy of Sleep Medicine, 2016-06-15) Selim, Bernardo J.; Koo, Brian B.; Qin, Li; Jeon, Sangchoon; Won, Christine; Redeker, Nancy S.; Lampert, Rachel J.; Concato, John P.; Bravata, Dawn M.; Ferguson, Jared; Strohl, Kingman; Bennett, Adam; Zinchuk, Andrey; Yaggi, Henry K.; Department of Medicine, IU School of Medicine
    STUDY OBJECTIVES: To determine whether sleep-disordered breathing (SDB) is associated with cardiac arrhythmia in a clinic-based population with multiple cardiovascular comorbidities and severe SDB. METHODS: This was a cross-sectional analysis of 697 veterans who underwent polysomnography for suspected SDB. SDB was categorized according to the apnea-hypopnea index (AHI): none (AHI < 5), mild (5 ≥ AHI < 15), and moderate-severe (AHI ≥ 15). Nocturnal cardiac arrhythmias consisted of: (1) complex ventricular ectopy, (CVE: non-sustained ventricular tachycardia, bigeminy, trigeminy, or quadrigeminy), (2) combined supraventricular tachycardia, (CST: atrial fibrillation or supraventricular tachycardia), (3) intraventricular conduction delay (ICD), (4) tachyarrhythmias (ventricular and supraventricular), and (5) any cardiac arrhythmia. Unadjusted, adjusted logistic regression, and Cochran-Armitage testing examined the association between SDB and cardiac arrhythmias. Linear regression models explored the association between hypoxia, arousals, and cardiac arrhythmias. RESULTS: Compared to those without SDB, patients with moderate-severe SDB had almost three-fold unadjusted odds of any cardiac arrhythmia (2.94; CI 95%, 2.01-4.30; p < 0.0001), two-fold odds of tachyarrhythmias (2.16; CI 95%,1.47-3.18; p = 0.0011), two-fold odds of CVE (2.01; 1.36-2.96; p = 0.003), and two-fold odds of ICD (2.50; 1.58-3.95; p = 0.001). A linear trend was identified between SDB severity and all cardiac arrhythmia subtypes (p value linear trend < 0.0001). After adjusting for age, BMI, gender, and cardiovascular diseases, moderate-severe SDB patients had twice the odds of having nocturnal cardiac arrhythmias (2.24; 1.48-3.39; p = 0.004). Frequency of obstructive respiratory events and hypoxia were strong predictors of arrhythmia risk. CONCLUSIONS: SDB is independently associated with nocturnal cardiac arrhythmias. Increasing severity of SDB was associated with an increasing risk for any cardiac arrhythmia.
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    Association Between Sleep-Related Leg Movements and Diabetes Prevalence: A Cohort Study From the United States
    (Springer Nature, 2025-05-23) Ding, Qinglan; Xie, Yuting; Koo, Brian B.; Hass, Zachary; Wojeck, Brian; Sico, Jason J.; Murray-Kolb, Laura E.; Bravata, Dawn M.; Zinchuk, Andrey; Medicine, School of Medicine
    Background: Sleep is integral to cardiometabolic health. While there is emerging evidence linking sleep-related leg movements (SRLM) to diabetes mellitus (DM), the underlying mechanisms remain unclear. This study investigates the association between SRLM and DM prevalence in a national population-based cohort study in the United States (US), considering potential mediators like short sleep duration and inflammation and examining variations across age, sex, and race/ethnicity. Methods: We analyzed data from 9,191 adults (aged ≥18 years) from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. We assessed the frequency of SRLM (leg jerks and leg cramps) and diabetes prevalence (self-reported diagnosis, diabetes medication use, or glycosylated hemoglobin (HbA1c) ≥ 6.5%). Weighted logistic regression models were used to evaluate the associations, adjusting for demographic and clinical-related confounders. Mediation analyses were conducted to explore the roles of short sleep duration and inflammation (C-reactive protein levels). Results: The study revealed that 1,278 (14%) participants have DM. SRLM was associated with a 72% increase in the odds of diabetes (OR=1.72, 95% CI: 1.06-2.81). The association is more pronounced in non-Hispanic White individuals, females, and adults aged 18-65. Short sleep duration and inflammation mediated 5.0% and 3.9% of this association, respectively. Conclusions: SRLM is independently and linearly associated with increased prevalence of diabetes in a representative sample of the US adult population. Short sleep duration and inflammation mediated a small part of this association. Confirming the association in other samples and further investigation into its mechanisms are warranted to better understand the roles of the SRLM in the risk of diabetes.