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Browsing by Author "Zhao, Xu"
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Item CoupleNet: Coupling Global Structure with Local Parts for Object Detection(IEEE, 2017-10) Zhu, Yousong; Zhao, Chaoyang; Wang, Jinqiao; Zhao, Xu; Wu, Yi; Lu, Hanqing; Medicine, School of MedicineThe region-based Convolutional Neural Network (CNN) detectors such as Faster R-CNN or R-FCN have already shown promising results for object detection by combining the region proposal subnetwork and the classification subnetwork together. Although R-FCN has achieved higher detection speed while keeping the detection performance, the global structure information is ignored by the position-sensitive score maps. To fully explore the local and global properties, in this paper, we propose a novel fully convolutional network, named as CoupleNet, to couple the global structure with local parts for object detection. Specifically, the object proposals obtained by the Region Proposal Network (RPN) are fed into the the coupling module which consists of two branches. One branch adopts the position-sensitive RoI (PSRoI) pooling to capture the local part information of the object, while the other employs the RoI pooling to encode the global and context information. Next, we design different coupling strategies and normalization ways to make full use of the complementary advantages between the global and local branches. Extensive experiments demonstrate the effectiveness of our approach. We achieve state-of-the-art results on all three challenging datasets, i.e. a mAP of 82.7% on VOC07, 80.4% on VOC12, and 34.4% on COCO. Codes will be made publicly available1.Item Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis(Wiley, 2021-03-08) Huang, Ying; Niu, Ming; Jing, Jing; Zhang, Zi-teng; Zhao, Xu; Chen, Shuai-shuai; Li, Shan-shan; Shi, Zhu; Huang, Ang; Zou, Zheng-Sheng; Yu, Yue-cheng; Xiao, Xiao-he; Liangpunsakul, Suthat; Wang, Jia-bo; Medicine, School of MedicineAlcohol-associated liver disease (ALD) is caused by alcohol metabolism's effects on the liver. The underlying mechanisms from a metabolic view in the development of alcohol-associated liver cirrhosis (ALC) are still elusive. We performed an untargeted serum metabolomic analysis in 14 controls, 16 patients with ALD without cirrhosis (NC), 27 patients with compensated cirrhosis, and 79 patients with decompensated ALC. We identified two metabolic fingerprints associated with ALC development (38 metabolites) and those associated with hepatic decompensation (64 metabolites) in ALC. The cirrhosis-associated fingerprint (eigenmetabolite) showed a better capability to differentiate ALC from NC than the aspartate aminotransferase-to-platelet ratio index score. The eigenmetabolite associated with hepatic decompensation showed an increasing trend during the disease progression and was positively correlated with the Model for End-Stage Liver Disease score. These metabolic fingerprints belong to the metabolites in lipid metabolism, amino acid pathway, and intermediary metabolites in the tricarboxylic acid cycle. Conclusion: The metabolomic fingerprints suggest the disturbance of the metabolites associated with cellular energy supply as an underlying mechanism in the development and progression of alcoholic cirrhosis.