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Browsing by Author "Zhang, Yanfeng"
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Item BMI, leisure-time physical activity, and physical fitness in adults in China: results from a series of national surveys, 2000–14(Elsevier, 2016-06) Tian, Ye; Jiang, Chongmin; Wang, Mei; Cai, Rui; Zhang, Yanfeng; He, Zihong; Wang, Huan; Wu, Dongming; Wang, Fubaihui; Tang, Qiang; Yang, Yang; Zhao, Jin; Lv, Shaojun; Zhou, Weihai; Yu, Bo; Lan, Jiang; Yang, Xinping; Zhang, Linxia; Tian, Hui; Gu, Zhuangzhuang; Song, Yiqing; Huang, Tianyi; McNaughton, Lars R.; Department of Epidemiology, Richard M. Fairbanks School of Public HealthBackground Obesity, physical inactivity, and reduced physical fitness contribute to the rising burden of chronic diseases in China. We investigated these factors in Chinese adults over a 14-year period (2000–14) using data from randomised national surveys. Methods We did four national surveys in 2000, 2005, 2010, and 2014 among Chinese adults aged 20–59 years. We used BMI to assess underweight (<18·5 kg/m2), overweight (≥23·0 to <27·5 kg/m2), and obesity (≥27·5 kg/m2). Central obesity was defined as a waist circumference greater than 90 cm in men and greater than 85 cm in women. We assessed leisure-time physical activity (LTPA) by whether or not participants had completed the recommended minimum 150 min of moderate or 75 min of vigorous exercise per week. Indices for assessment of physical fitness were forced vital capacity, resting heart rate, hand grip strength, sit and reach distance, and time standing on one leg. Findings 151 656 (78%) of 193 440 adults responded to the survey in 2000, 163 386 (84%) in 2005, 154 931 (80%) in 2010, and 146 703 (76%) in 2014. The prevalence of obesity increased from 8·6% in 2000, to 10·3% in 2005, 12·2% in 2010, and 12·9% in 2014 (estimated increase 0·32% per year, 95% CI 0·30–0·33; p<0·0001). The equivalent estimates were 37·4%, 39·2%, 40·7%, and 41·2% for overweight (estimated increase 0·27% per year, 95% CI 0·25–0·30; p<0·0001) and 13·9%, 18·3%, 22·1%, and 24·9% for central obesity (estimated increase 0·78% per year, 0·76–0·80; p<0·0001). The prevalence of overweight, obesity, and central obesity increased with age (all p<0·0001) and was higher in men than in women (all p<0·0001). We noted a simultaneous decrease in the prevalence of underweight (estimated decrease of 0·06% per year, 95% CI 0·04–0·07; p<0·0001). The proportion of adults meeting the minimum LTPA recommendation increased over time (17·2% in 2000, 18·1% in 2005, and 22·8% in 2014), with the estimated prevalence change per year being 0·33% (95% CI 0·24–0·42; p<0·0001) for underweight people, 0·50% (0·47–0·53; p<0·0001) for normal-weight people, 0·37% (0·34–0·40; p<0·0001) for overweight people, and 0·06% (0·00–0·13; p=0·044) for obese people. We noted deteriorations over time in all measures of physical fitness in normal-weight adults (all p<0·0001), apart from resting heart rate (p=0·69). Interpretation Despite increased participation in LTPA, we noted increases in overweight or obesity and a decrease in physical fitness in Chinese adults. Continued nationwide interventions are needed to promote physical activity and other healthy lifestyle behaviours in China.Item Long intergenic non-coding RNA expression signature in human breast cancer(SpringerNature, 2016-11-29) Zhang, Yanfeng; Wagner, Erin K.; Guo, Xingyi; May, Isaac; Cai, Qiuyin; Zheng, Wei; He, Chunyan; Long, Jirong; Department of Epidemiology, Richard M. Fairbanks School of Public HealthBreast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. We designed a two-stage study, including 1,000 breast tumor RNA-seq data from The Cancer Genome Atlas (TCGA) as the discovery stage, and RNA-seq data of matched tumor and adjacent normal tissue from 50 breast cancer patients as well as 23 normal breast tissue from healthy women as the replication stage. We identified 83 lincRNAs showing the significant expression changes in breast tumors with a false discovery rate (FDR) < 1% in the discovery dataset. Thirty-seven out of the 83 were validated in the replication dataset. Integrative genomic analyses suggested that the aberrant expression of these 37 lincRNAs was probably related with the expression alteration of several transcription factors (TFs). We observed a differential co-expression pattern between lincRNAs and their neighboring genes. We found that the expression levels of one lincRNA (RP5-1198O20 with Ensembl ID ENSG00000230615) were associated with breast cancer survival with P < 0.05. Our study identifies a set of aberrantly expressed lincRNAs in breast cancer.