Browsing by Author "Zhang, Daiwei"

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    Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology
    (Springer Nature, 2024) Zhang, Daiwei; Schroeder, Amelia; Yan, Hanying; Yang, Haochen; Hu, Jian; Lee, Michelle Y. Y.; Cho, Kyung S.; Susztak, Katalin; Xu, George X.; Feldman, Michael D.; Lee, Edward B.; Furth, Emma E.; Wang, Linghua; Li, Mingyao; Pathology and Laboratory Medicine, School of Medicine
    Spatial transcriptomics (ST) has demonstrated enormous potential for generating intricate molecular maps of cells within tissues. Here we present iStar, a method based on hierarchical image feature extraction that integrates ST data and high-resolution histology images to predict spatial gene expression with super-resolution. Our method enhances gene expression resolution to near-single-cell levels in ST and enables gene expression prediction in tissue sections where only histology images are available.